A new recombinant protein comprising polypeptides bearing epitopes of human papilloma virus (HPV) antigens; useful for treating or preventing HPV infection, or for immunotherapy against the onset of malignant transformation due to HPV infection.

A new composition that comprises contacting an antigen-presenting cell with a chimeric antigen comprising an immune response domain and a target binding domain, which comprises a xenotypic antibody fragment; useful for eliciting a T-cell response against hepatitis B virus and hepatitis C virus infections.

A new isolated polypeptide that binds specifically to an oligosaccharide; useful in preparing a vaccine for treating or preventing HIV infection.

A method for making a recombinant avian herpesvirus, comprising cotransfecting overlapping subgenomic fragments employing the subgenomic clones and enzymes; useful in producing therapeutic or prophylactic vaccines.

A novel recombinant varicella herpes-zoster virus comprising a bacterial artificial chromosome vector sequence; useful as a vaccine for treating varicella herpes-zoster virus infection.

A novel recombinant or synthetic hepatitis C virus E1 envelope protein or its portion comprising one or more disulfide bonds between a specific pair of cysteines; useful as vaccine for hepatitis C virus.

A novel nucleic acid encoding chimeric polypeptides such as calreticulin and antigenic peptide from severe acute respiratory syndrome (SARS) coronavirus; useful as a DNA vaccine for SARS coronavirus.

A method for inactivating and purifying SARS virus; useful for preparing vaccines to combat SARS.

A new fusion protein useful as a vaccine for treating and preventing influenza.

A totally enclosed double-circulating column chromatography process for purifying inactivated virus vaccines.

A technique for preparing a virus vaccine using a bioreactor featuring a disk carrier for increasing the surface area used to grow cells, and a better culture condition created for increasing the culture density.

Use of an organic precursor compound for the formation of a homogeneous organic film on a (semi)conductor electric surface; useful for microelectronic components and biomedical devices.

New functionalized drugs useful for treating and preventing cancerous disease, reducing pain and inflammation, and in implantable biomedical devices and polymeric compositions, such as bioabsorbable chewing gum.

A prepolymer used for hydrogel copolymers, with a polymerizable ethylenically unsaturated radical, diradical residue of diisocyanate, diradical residue of polysiloxane diol and diradical residue of diol; useful for increasing oxygen permeability, tensile modulus and water content in biomedical devices, especially ophthalmic devices such as contact lenses, intraocular lenses and ophthalmic implants.

A method for improving parylene-to-parylene adhesion in, e.g., a biomedical device, comprising providing a device having multiple parylene layers on a substrate in a vacuum chamber, and heating at least two adjacent parylene layers to a temperature that is greater than a deposition temperature at which the parylene layers were formed to enhance adhesion of the parylene layers.

A nanotube/polymer composite resistant to ionizing radiation, produced by sonicating single-wall carbon nanotubes, introducing polymethylmethacrylate into the nanotubes to form a polymethylmethacrylate/single-wall nanotube mixture, and sonicating the mixture; used in the manufacture of biomedical devices.

Nitrogen-containing heterobicyclic compounds useful for the treatment of a cancerous condition, e.g., acute lymphocytic leukemia, cancer of the adrenal cortex, breast cancer, liver cancer, pancreatic cancer and prostate cancer, and a method for eliminating teratoma-forming stem cells prior to transplant into a mammalian subject involving incubating a stem cell culture with the heterobicyclic compound.

A method for culturing stem cells using ATP-Binding Cassette transporters (ABC transporters) by bringing a stem cell culture into contact with an anti-tumor drug or toxin as a substrate of ABC transporters to allow the substrate to react with the stem cell culture, and reculturing viable cells among the stem cell culture which reacted with the substrate, the viable cells having no substrate introduced in it.

A method for producing collagen such as collagen type 14 or collagen type 12, involving introducing a vector containing myodifferentiation inducer factor into a cell; the cell is derived from an animal, preferably mouse mesodermal stem cell culture strain MC3T3-E1, ATDC5 or C3H10T 1/2.

A serum-free medium for culturing animal stem cells, obtained by adding an antimicrobial peptide to a basal medium for animal cell culture, which does not contain blood serum; enables excellent and efficient culture and proliferation of animal stem cells equivalent to the medium comprising blood serum, reduces the risk of infection during the culture and obtains cells free from infections such as viral infections and BSE.

A composition comprising a phenol derivative or its salt as an active ingredient; useful for treating bacterial and viral infections in pharmaceuticals, agrochemicals and as a disinfectant.

An antiviral artificial cell comprising an artificial cytoskeleton comprising an electromagnetic wave absorber that generates heat to neutralize a virus when externally irradiated with an electromagnetic wave, an artificial cytomembrane wrapping the artificial cytoskeleton and a nanoparticle having a magnetic spin, rotatably retained on the artificial cytomembrane and having a surface for capturing a virus. Useful as an antiviral drug used in a biofilter for removing virus.

A medical treatment method, or antiviral drug or riboflavin (vitamin B2) drug for viral infection, preferably AIDS caused by HIV, having an envelope, involving using diethyl ether or a substance such as pancreas lipase, bile acid, chitosan, acetone, ethanol, newlase etc., where the concentration of the substance is not altered.

A method for making a system for delivering drugs (e.g., antibiotic, anti-inflammatory, antihistamine, antiviral agent, cancer drug or anesthetic) involving forming a recognitive polymer hydrogel into contact lenses.

A method of isolating an miRNA sample from skin comprising applying an adhesive tape to a target area of the skin in a manner to isolate an epidermal sample, where the epidermal sample contains miRNA, where the tape comprises a rubber adhesive, and where the tape is pliable, thus isolating an epidermal sample adhering to the adhesive tape.

A new array of oligonucleotide probes comprising probes that selectively bind a mature mRNA and a platform on which the probes are immobilized; useful for identifying miRNAs in a sample.

A method of detecting the tissue origin of cancer comprising contacting a sample derived from a sample containing tumor cells with detection probe, which is a member from a collection of detection probes, the collection of detection probes being capable of specifically identifying target RNA sequences in all miRNAs of the mammal.

A microarray for miRNA detection comprising a capture probe of endogenic low–molecular weight RNA. The microarray enables comprehensive and efficient analysis and detection of miRNA and can correctly track time-dependent expression change of miRNA by conducting a relative miRNA expression analysis.

A method of purifying mature miRNAs comprises lysing the sample, degrading the additional nucleic acids and liberating the mature miRNAs.

A method of isolating an miRNA sample from skin comprising applying an adhesive tape to a target area of the skin in a manner to isolate an epidermal sample, where the epidermal sample contains miRNA, where the tape comprises a rubber adhesive, and where the tape is pliable, thus isolating an epidermal sample adhering to the adhesive tape.

A new array of oligonucleotide probes comprising probes that selectively bind a mature mRNA and a platform on which the probes are immobilized; useful for identifying miRNAs in a sample.

A method of detecting the tissue origin of cancer comprising contacting a sample derived from a sample containing tumor cells with detection probe, which is a member from a collection of detection probes, the collection of detection probes being capable of specifically identifying target RNA sequences in all miRNAs of the mammal.

A microarray for miRNA detection comprising a capture probe of endogenic low–molecular weight RNA. The microarray enables comprehensive and efficient analysis and detection of miRNA and can correctly track time-dependent expression change of miRNA by conducting a relative miRNA expression analysis.

A method of purifying mature miRNAs comprises lysing the sample, degrading the additional nucleic acids and liberating the mature miRNAs.