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Systems Bio & Personalized Med
Personalized Medicine: Molecular Imaging Predicts Treatment Success in Many Cancers PDF Print E-mail
Thursday, 02 September 2010 03:52

A series of studies published in the September Journal of Nuclear Medicine (JNM) shows that molecular imaging plays a critical role in the evaluation and treatment planning for a broad spectrum of cancers, including thyroid cancer and lymphoma.

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Nanobiotechnology Advances Point to Medical Applications PDF Print E-mail
Thursday, 02 September 2010 03:48

Two new groundbreaking scientific papers by researchers at UC Santa Barbara demonstrate the synthesis of nanosize biological particles with the potential to fight cancer and other illnesses. The studies introduce new approaches that are considered "green" nanobiotechnology because they use no artificial compounds.

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Sensitivity to Alcohol Odors May Indicate a Genetic Predisposition to Alcohol Dependence PDF Print E-mail
Thursday, 02 September 2010 03:42

Single nucleotide polymorphisms (SNPs) are DNA sequence variations that occur when a single nucleotide in the genome sequence is altered. Prior research suggested an association between SNPs in a gene that encodes aspects of the brain's gamma-amino butyric acid (GABA)-A receptors (the GABRA2 gene) and alcohol dependence. A study of responses to the aromas of alcoholic drinks according to subjects' genotyping at a SNP in GABRA2 has found that this genotype can affect the brain's reward responses to cues such as alcohol odors.

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UBC Researchers Unveil 'toolbox Of MiniPromoters' For Gene Research And Therapy PDF Print E-mail
Tuesday, 31 August 2010 06:34

University of British Columbia researchers have led the development of a new "toolbox of MiniPromoters" for research and future therapies on brain, spinal cord and eye function.

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Stress Protein Hsp12 Provides A Cellular Survival Mechanism Never Seen Before PDF Print E-mail
Saturday, 28 August 2010 03:34

Despite clear evidence that Hsp12 -- a so-called heat shock or stress protein -- helps cells survive life-threatening conditions, how it works was an open question until now. The surprising answer is revealed in the Aug. 27 issue of Molecular Cell, where German researchers explain how they discovered the function of Hsp12, a protective mechanism unlike any previously observed. Unfolded within the cell's aqueous cytosol, Hsp12 folds into helical structures to stabilize the cell membrane.

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Genome Comparison Of Ants Establishes New Model Species For Molecular Research PDF Print E-mail
Saturday, 28 August 2010 03:30

By comparing two species of ants, Shelley Berger, PhD, the Daniel S. Och University Professor at the University of Pennsylvania, and colleagues Danny Reinberg, PhD, New York University, and Juergen Liebig, PhD, Arizona State University, have established an important new avenue of research for epigenetics -- the study of how the expression or suppression of particular genes affects an organism's characteristics, development, and even behavior.

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Genetic Rarity Found: A Mutation That Restores Health PDF Print E-mail
Saturday, 28 August 2010 03:20

Errors in the copying of genes during cell division can cause numerous diseases, including cancer. Yale School of Medicine scientists, however, have unraveled the secrets of a much more rare phenomenon with potential therapeutic implications -- disease-causing genes that show a high frequency of self-repair.

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Exposure to Low Doses of BPA Alters Gene Expression in the Fetal Mouse Ovary PDF Print E-mail
Thursday, 26 August 2010 03:05

A new study published online in the journal Biology of Reproduction finds that exposure of pregnant female mice to the endocrine-disrupting chemical bisphenol A may produce adverse reproductive consequences on gene expression in fetal ovaries as early as 12 hours after the mother has first been exposed to the chemical.

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Gene Involved in Fuchs Corneal Dystrophy Is Found PDF Print E-mail
Thursday, 26 August 2010 02:50

A 13-member research team led by University of Oregon scientist Dr. Albert O. Edwards has found a gene likely responsible for Fuchs corneal dystrophy, an inheritable genetic disorder and leading cause of corneal transplant operations.

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Regulation Of Cell Proliferation Is Dependent On Nucleocytoplasmic Trafficking PDF Print E-mail
Tuesday, 24 August 2010 05:40

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the Opioid Growth Factor (OGF, [Met5]-enkephalin) and its receptor, OGFr, a clinically important system with potent antitumor properties, has controlled entry from the cytoplasm to the nucleus.

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Personalized Medicine: Molecular Imaging Predicts Treatment Success in Many Cancers PDF Print E-mail
Thursday, 02 September 2010 03:52

A series of studies published in the September Journal of Nuclear Medicine (JNM) shows that molecular imaging plays a critical role in the evaluation and treatment planning for a broad spectrum of cancers, including thyroid cancer and lymphoma.

Read more...
 
Live Imaging Puts New Light on Stem Cell Division PDF Print E-mail
Thursday, 02 September 2010 03:44

A long-held assumption about asymmetrical division of stem cells has cracked. Researchers at the University of Oregon report that the mitotic spindle does not act alone -- that cortical proteins help to position a cleavage furrow in the right location.

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Researchers To Activate Anti-Cancer Gene PDF Print E-mail
Tuesday, 31 August 2010 06:45

smaller components and Human intestines then transported through the gut wall and onwards to muscles and organs. The lining of the gut is coated in epithelial cells, a specialised layer that produces mucous and hormones while keeping dangerous bacteria and toxins at bay. Close contact with pathogenic microbes and toxins means that the epithelial cells may mutate to form cancer. The small intestine therefore secretes the entire epithelial layer in the course of two to five days, while the large intestine takes three weeks to perform the same process.

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'Toolbox of MiniPromoters' for Gene Research and Therapy Created PDF Print E-mail
Tuesday, 31 August 2010 05:45

University of British Columbia researchers have led the development of a new "toolbox of MiniPromoters" for research and future therapies on brain, spinal cord and eye function.

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Fat Serves As Cells' Built-In PH Sensor: UBC Research PDF Print E-mail
Saturday, 28 August 2010 03:32

A specific type of fat present in cell membranes also serves as a cellular pH sensor, a team of University of British Columbia researchers has discovered.

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Acidity Regulates Cell Membrane Synthesis PDF Print E-mail
Saturday, 28 August 2010 03:25

Acidity (pH) in cells of baker's yeast, Saccharomyces cerevisiae, regulate the synthesis of cell membranes by controlling the production of enzymes that synthesize membranes. These are the findings of researchers at the University of British Columbia in Vancouver, Canada, in close collaboration with systems biologists at the University of Amsterdam (UvA). The results of this research have just been published in the journal Science. The elucidated mechanism is so simple and universal that it is highly likely that it determines many processes in the cell in all forms of life.

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Waiting for the Right Moment: Bacterial Pathogens Delay Their Entry Into Cells PDF Print E-mail
Thursday, 26 August 2010 03:08

Certain pathogens make themselves at home in the human body by invading cells and living off the plentiful amenities on offer there. However, researchers at the Max Planck Institute for Infection Biology, Berlin, together with colleagues at Harvard University, have discovered a contrary strategy to ensure infection success: some pathogens can actually delay their entry into cells to ensure their survival. Upon contact with a cell, these bacteria engage signalling molecules in the cell and trigger a local strengthening of the cellular skeleton that resists pathogen entry. This strategy, unknown until now, is used by the sexually transmitted bacterium Neisseria gonorrhoeae, as well as by an important intestinal pathogen.

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Hydrophobic Proteins: Potential Biomarkers for Colorectal Cancer PDF Print E-mail
Thursday, 26 August 2010 02:59
Colorectal cancer, cancer of the colon and rectum, is a common cause of mortality worldwide. Statistical data showed that the number of deaths caused by colorectal cancer is increasing in both men and women. Proteins are functional components of the cell that regulate the cell's activity. Understanding the differential expression of proteins in colorectal cancer and normal tissues will lead to a better understanding of the development of the disease. Furthermore, these proteins may serve as biomarkers for treatment or detection of the disease. Hydrophobic proteins play a vital role in various cellular processes, by virtue of their cellular location, and may serve as a target for drug-targeted therapy.
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Eating Berries May Activate The Brain's Natural Housekeeper For Healthy Aging PDF Print E-mail
Tuesday, 24 August 2010 05:46

Scientists today reported the first evidence that eating blueberries, strawberries, and acai berries may help the aging brain stay healthy in a crucial but previously unrecognized way. Their study, presented at the 240th National Meeting of the American Chemical Society (ACS), concluded that berries, and possibly walnuts, activate the brain's natural "housekeeper" mechanism, which cleans up and recycles toxic proteins linked to age-related memory loss and other mental decline.

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Gene Scan Finds Link Across Array Of Childhood Brain Disorders PDF Print E-mail
Tuesday, 24 August 2010 05:37

Mutations in a single gene can cause several types of developmental brain abnormalities that experts have traditionally considered different disorders. With support from the National Institutes of Health, researchers found those mutations through whole exome sequencing – a new gene scanning technology that cuts the cost and time of searching for rare mutations.

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