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Stem Cells
Packaging stem cells in capsules for heart therapy PDF Print E-mail
Saturday, 12 October 2013 21:19

 

Story image Alginate has several biomedical uses already. It's used in wound dressings and in the goop dentists use to make dental impressions. Here it forms capsules around mesenchymal stem cells. 

Stem cell therapy for heart disease is happening. Around the world, thousands of heart disease patients have been treated in clinical studies with some form of bone marrow cells or stem cells. But in many of those studies, the actual impact on heart function was modest or inconsistent. One reason is that most of the cells either don’t stay in the heart or die soon after being introduced into the body.

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Stem cell discovery furthers research on cell-based therapy and cancer PDF Print E-mail
Saturday, 20 July 2013 22:27

Stem-cell researchers at UC San Francisco have found a key role for a protein called BMI1 that may help scientists direct the development of tissues to replace damaged organs in the human body.

“Scientists have known that Bmi1 is a central control switch within the adult stem cells of many tissues, including the brain, blood, lung and mammary gland,” said Ophir Klein, MD, PhD, who directs the Craniofacial and Mesenchymal Biology (CMB) Program and serves as chair of the Division of Craniofacial Anomalies at UCSF. “Bmi1 also is a cancer-causing gene that becomes reactivated in cancer cells.”

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Injecting iron supplement lets Stanford scientists track transplanted stem cells PDF Print E-mail
Saturday, 13 July 2013 21:21

STANFORD, Calif. — A new, noninvasive technique for tracking stem cells after transplantation — developed by a cross-disciplinary team of radiologists, chemists, statisticians and materials scientists at the Stanford University School of Medicine — could help surgeons determine whether a procedure to repair injured or worn-out knees is successful.

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Toronto team IDs proteins key in stem cell production PDF Print E-mail
Saturday, 06 July 2013 16:38

TORONTO - A team of Toronto-based researchers may be one step closer to a 'recipe' for large-scale production of stem cells for use in research and therapy.

Induced pluripotent stem cells (iPSCs) can be of great value for medical research because they can flexibly develop into many different types of cells. However, producing these cells is challenging because the proteins that control their generation are largely unknown.

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Alzheimer's, Schizophrenia, and Autism Now Can Be Studied With Mature Brain Cells Reprogrammed from Skin Cells PDF Print E-mail
Saturday, 08 June 2013 22:15

5 June 2013 — Difficult-to-study diseases such as Alzheimer's, schizophrenia, and autism now can be probed more safely and effectively thanks to an innovative new method for obtaining mature brain cells called neurons from reprogrammed skin cells. According to Gong Chen, the Verne M. Willaman Chair in Life Sciences and professor of biology at Penn State University and the leader of the research team, "the most exciting part of this research is that it offers the promise of direct disease modeling, allowing for the creation, in a Petri dish, of mature human neurons that behave a lot like neurons that grow naturally in the human brain." Chen added that the method could lead to customized treatments for individual patients based on their own genetic and cellular information. The research will be published in the journal Stem Cell Research.

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U of M researchers discover link between heart, blood, and skeletal muscle PDF Print E-mail
Sunday, 05 May 2013 00:32
Gene thought to make heart tissues turns out to make blood and muscles as well

New research out of the Lillehei Heart Institute at the University of Minnesota shows that by turning on just a single gene, Mesp1, different cell types including the heart, blood and muscle can be created from stem cells. The study was published in the journal Cell Stem Cell.

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One of the key circuits in regulating genes involved in producing blood stem cells is deciphered PDF Print E-mail
Saturday, 02 February 2013 01:03

The finding will, in the future, allow obtaining cells in a lab for therapeutic purposes.

Researchers from the group on stem cells and cancer at IMIM (Hospital del Mar Medical Research Institute) have deciphered one of the gene regulation circuits which would make it possible to generate hematopoietic blood cells, i.e. blood tissue stem cells. This finding is essential to generate these cells in a laboratory in the future, a therapy that could benefit patients with leukaemia or other diseases who need a transplant and who, in many cases, do not have a compatible donor.

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Stem cells develop best in 3D PDF Print E-mail
Saturday, 24 November 2012 13:55

The research suggests that in the laboratory beta cells  can develop better from stem cells in 3D. Photo: Joan Goulley THREE-DIMENSIONAL 

Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen are contributing important knowledge about how stem cells develop best into insulin-producing cells. In the long term this new knowledge can improve diabetes treatment with cell therapy. The results have just been published in the scientific journal Cell Reports.

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Solving Stem Cell Mysteries PDF Print E-mail
Friday, 26 October 2012 22:19

Baltimore, MD— The ability of embryonic stem cells to differentiate into different types of cells with different functions is regulated and maintained by a complex series of chemical interactions, which are not well understood. Learning more about this process could prove useful for stem cell-based therapies down the road. New research from a team led by Carnegie’s Yixian Zheng zeroes in on the process by which stem cells maintain their proper undifferentiated state. Their results are published in CellOctober 26.

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Discovery of Reprogramming Signature May Help Overcome Barriers to Stem Cell-Based Regenerative Medicine PDF Print E-mail
Sunday, 23 September 2012 03:40

ScienceDaily (Sep. 18, 2012) — Salk scientists have identified a unique molecular signature in induced pluripotent stem cells (iPSCs), "reprogrammed" cells that show great promise in regenerative medicine thanks to their ability to generate a range of body tissues.

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Human stem cell-derived hepatocytes regenerate liver function PDF Print E-mail
Saturday, 27 July 2013 15:08

And extend survival in mice with hepatic failure.

New Rochelle, NY, July 26, 2013 -- Researchers have generated functional hepatocytes from human stem cells, transplanted them into mice with acute liver injury, and shown the ability of these stem-cell derived human liver cells to function normally and increase survival of the treated animals. This promising advance in the development of cell-based therapies to treat liver failure resulting from injury or disease relied on the development of scalable, reproducible methods to produce stem cell-derived hepatocytes in bioreactors, as described in an article in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Stem Cells and Developmentwebsite.

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Stem cell clues uncovered PDF Print E-mail
Saturday, 13 July 2013 21:54

Baltimore, MD—Proper tissue function and regeneration is supported by stem cells, which reside in so-called niches. New work from Carnegie's Yixian Zheng and Haiyang Chen identifies an important component for regulating stem cell niches, with impacts on tissue building and function. The results could have implications for disease research. It is published byCell Stem Cell.

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Exercise rescues mutated neural stem cells PDF Print E-mail
Saturday, 06 July 2013 17:23

CHARGE syndrome* is a severe developmental disorder affecting multiple organs. It affects 1 in 8500 newborns worldwide. The majority of patients carry a mutation in a gene called CHD7. How this single mutation leads to the broad spectrum of characteristic CHARGE symptoms has been a mystery.

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USF study links cardiac hormone-related inflammatory pathway with tumor growth PDF Print E-mail
Sunday, 30 June 2013 14:57

Mohapatra_Subhra_600x400Tampa, FL (June 28, 2013) – A cardiac hormone signaling receptor abundantly expressed both in inflamed tissues and cancers appears to recruit stem cells that form the blood vessels needed to feed tumor growth, reports a new study by scientists at the University of South Florida Nanomedicine Research Center

The research may lead to the development of new drugs or delivery systems to treat cancer by blocking this receptor, known as natriuretic peptide receptor A (NPRA).

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UCLA stem cell researchers move toward treatment for rare genetic nerve disease PDF Print E-mail
Friday, 10 May 2013 23:04

Disease-in-a-dish models show promise for treating ataxia telangiectasia

Led by Dr. Peiyee Lee and Dr. Richard Gatti, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have used induced pluripotent stem (iPS) cells to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia (A-T).

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Stem cells enable personalised treatment for bleeding disorder PDF Print E-mail
Saturday, 06 April 2013 16:30

main imageCells from patients' blood could be developed as treatments for heart and circulatory diseases.

Scientists have shed light on a common bleeding disorder by growing and analysing stem cells from patients’ blood to discover the cause of the disease in individual patients.

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Temple scientists target DNA repair to eradicate leukemia stem cells PDF Print E-mail
Sunday, 09 December 2012 21:54

(Philadelphia, PA) – Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant to treatment and may even accumulate additional genetic aberrations, eventually leading to disease progression and relapse. These leukemia stem cells are full of genetic errors, loaded with potentially lethal breaks in DNA, and are in a state of constant self-repair.

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Stanford/Yale study gives insight into subtle genomic differences among our own cells PDF Print E-mail
Monday, 19 November 2012 01:16

STANFORD, Calif. — Stanford University School of Medicine scientists have demonstrated, in a study conducted jointly with researchers at Yale University, that induced-pluripotent stem cells — the embryonic-stem-cell lookalikes whose discovery a few years ago won this year's Nobel Prize in medicine — are not as genetically unstable as was thought.

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Stem cells from muscle tissue may hold key to cell therapies for neurodegenerative diseases PDF Print E-mail
Saturday, 13 October 2012 20:40

WINSTON-SALEM, N.C. – Oct. 12, 2012 – Scientists at Wake Forest Baptist Medical Center have taken the first steps to create neural-like stem cells from muscle tissue in animals. Details of the work are published in two complementary studies published in the September online issues of the journals Experimental Cell Research and Stem Cell Research.

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Einstein hosts its first stem cell institute symposium PDF Print E-mail
Sunday, 23 September 2012 03:24

September 21, 2012 – (BRONX, NY) – The promise of stem cells seems limitless. If they can be coaxed into rebuilding organs, repairing damaged spinal cords and restoring ravaged immune systems, these malleable cells would revolutionize medical treatment. But stem cell research is still in its infancy, as scientists seek to better understand the role of these cells in normal human development and disease.

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