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Friday, 13 May 2011 00:21 |
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MicroRNAs (miRNAs) are prevalent and important endogenous gene regulators in eukaryotes. miR159 and miR319 are highly conserved miRNAs essential for plant development and fertility.
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Monday, 09 May 2011 01:58 |
 Cancer researchers at UT Southwestern Medical Center are helping unlock the cellular-level function of the telomerase enzyme, which is linked to the disease’s growth.
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Friday, 06 May 2011 03:56 |
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Bioo Scientific launched the patent pending NEXTflex™ Small RNA Sequencing Kit which provides an easy, flexible, cost-effective solution for generating single and multiplexed libraries from small RNA using Illumina GAIIx and HiSeq 2000 sequencing platforms.
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Friday, 06 May 2011 03:16 |
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Molecular Templates, Inc., a biopharmaceutical company focused on the discovery and development of a new class of small biologic therapies called Engineered Toxin Bodies (ETB), announced that it has entered into a research collaboration with Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, to evaluate and develop Molecular Templates’ proprietary technology for targeted delivery of RNAi therapies. No financial terms were disclosed.
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Monday, 02 May 2011 00:55 |
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Beta-Amyloid protein (Abeta) has been shown to potentiate the caspase-3 activation induced by the commonly used inhalation anesthetic isoflurane. However, it is unknown whether reduction in Abeta levels can attenuate the isoflurane-induced caspase-3 activation.
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Friday, 29 April 2011 02:24 |
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Scientists at the Gladstone Institutes have identified networks of genes that play an important role in embryonic-heart development, advancing knowledge of how healthy hearts develop—and offering clues about how to combat a common birth defect known as congenital heart disease.
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Friday, 29 April 2011 00:18 |
 Eating more n-3 polyunsaturated fatty acids, commonly known as omega-3 fatty acids, may help carriers of a genetic variant on the perilipin 4 (PLIN4) gene locus lose weight more efficiently. Based on this observation, researchers at the Jean Mayer Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University identified a microRNA (miRNA) which may elucidate the underlying biological mechanism.
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Monday, 25 April 2011 01:50 |
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RNA interference technology, which is used in cell biology, has revolutionised functional research of the gene products in the last ten years. VTT Technical Research Centre of Finland has developed a method which allows a single microchip to be used to screen the functions of tens of thousands of genes simultaneously by means of RNA interference.
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Friday, 22 April 2011 02:45 |
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The differentiation of CD8+ T lymphocytes following priming of naive cells is central in the establishment of the adaptive immune response. Yet, the molecular events underlying this process are not fully understood
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Friday, 22 April 2011 00:17 |
 RNA interference technology, which is used in cell biology, has revolutionised functional research of the gene products in the last ten years. VTT Technical Research Centre of Finland has developed a method which allows a single microchip to be used to screen the functions of tens of thousands of genes simultaneously by means of RNA interference.
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Monday, 09 May 2011 01:59 |
 A University of Cincinnati (UC) research team led by biomedical engineering professor Peixuan Guo, has recently released two articles in the online journal, Molecular Therapy, describing how he has developed large RNA nanoparticles.
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Monday, 09 May 2011 01:57 |
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Oocyte-derived maternal RNAs drive early embryogenesis when the newly formed embryo is transcriptionally inactive. Recent studies in zebrafish have identified the role of microRNAs during the maternal-to-embryonic transition (MET).
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Friday, 06 May 2011 03:53 |
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A novel and more efficient method of generating iPS (induced pluripotent stem) cells from adult cells using small RNA molecules has been discovered by researchers at the University of Pennsylvania School of Medicine in the USA.
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Wednesday, 04 May 2011 03:51 |
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Rosetta Genomics, Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, announces that results of a joint study with researchers at the University of Texas, M. D. Anderson Cancer Center show that Rosetta Genomics' miRview™ mets is a powerful tool to identify Tissue of Origin in Carcinoma of Unknown Primary (CUP) patients.
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Monday, 02 May 2011 00:54 |
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Argonaute, the core component of the RNA induced silencing complex (RISC), binds to mature miRNAs and regulates gene expression at transcriptional or post-transcriptional level. We recently reported that Argonaute 2 (Ago2) also assembles into complexes with miRNA precursors (pre-miRNAs).
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Friday, 29 April 2011 01:21 |
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 A group of researchers at the Ohio State University Comprehensive Cancer Center has discovered that a certain type of RNA, microRNA-155, may provide the link between inflammation and cancer. The article describing the study was published online ahead of print in PNAS in March (doi: 10.1073/pnas.1101795108).
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Monday, 25 April 2011 02:17 |
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MicroRNAs are a family of ~22nt small RNAs that can regulate gene expression at the post-transcriptional level. Identification of these molecules and their targets can aid understanding of regulatory processes.
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Monday, 25 April 2011 00:54 |
 Nanotechnology researchers have known for years that RNA, the cousin of DNA, is a promising tool for nanotherapy, in which therapeutic agents can be delivered inside the body via nanoparticles.
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Friday, 22 April 2011 01:42 |
 Researchers at the University of Pennsylvania School of Medicine are delving into the details of the complex structure at the ends of chromosomes. Recent work, published online in Nature Structural & Molecular Biology, describes how these structures, called telomeres, can be protected by caps made up of specialized proteins and stacks of DNA called G-quadruplexes, or "G4 DNA."
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Monday, 18 April 2011 01:25 |
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Researchers are using high-density lipoproteins (HDLs) to carry siRNAs that inhibit genes involved in cancer attacked ovarian cancer tumors in mice.
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