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Friday, 03 September 2010 18:30 |
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A new rapid-fire technique for visualizing the structure of RNA in a cell could revolutionize the way scientists study this vital molecule. Unlike earlier techniques, which are labor-intensive and only yield the structure of one short strand of RNA at a time, the new process uses a parallel-processing approach to provide—for the first time—a global view of a species’ diverse RNA structures.
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Friday, 03 September 2010 12:29 |
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Marina Biotech, Inc., a leading RNAi-based drug discovery and development company, today announced that the U.S. Patent and Trademark Office has issued a Notice of Allowance for patent application U.S. 11/745,003 broadly covering amphoteric liposomal formulations, including the Company's proprietary SMARTICLES(R) technology, for delivery of siRNAs and other compounds with therapeutic application.
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Wednesday, 01 September 2010 14:02 |
It seems there is no limit to the Rockefeller Foundation’s ambitions to introduce anti-fertility compounds into either existing “health-services”, such as vaccines, or- as appears to be the case now- average consumer-products.
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Monday, 30 August 2010 18:01 |
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MirSVR is a new machine learning method for ranking microRNA target sites by a down-regulation score. The algorithm trains a regression model on sequence and contextual features extracted from miRanda-predicted target sites.
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Monday, 30 August 2010 16:06 |
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Chronic drinking can disrupt production of the genes that control the body's daily biological (circadian) rhythms, leading to problems such as sleep disruption and mood changes, new research reports.
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Friday, 27 August 2010 14:12 |
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The National Institutes of Health this month set aside nearly $400,000 to fund three research projects focused on microRNAs and the heart, including one issued to a company aiming to develop an miRNA antagonist to prevent cardiac ischemia.
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Wednesday, 25 August 2010 18:27 |
Alnylam Pharmaceuticals, Inc. /quotes/comstock/15*!alny/quotes/nls/alny (ALNY 13.63, -0.12, -0.87%) , a leading RNAi therapeutics company, announced today that it will make a total of 16 oral presentations at the American Chemical Society (ACS) Fall 2010 240th National Meeting & Exposition being held in Boston, Mass. from August 22-26, 2010.
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Monday, 23 August 2010 18:29 |
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Researchers from LC Sciences LLC and a collaboration of Universities(1) have established a porcine microRNAome, a complete catalog of all microRNAs expressed in the species Sus scrofa(2). MicroRNAs (miRNAs) are small regulatory RNA molecules known to control a wide array of cellular functions such as growth and development and whose dysregulation has been associated with disease.
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Friday, 20 August 2010 18:37 |
Researchers at Tufts University School of Medicine and Tufts Medical Center have identified an RNA sequence that promotes increased numbers of specific microRNAs (miRNAs), molecules that regulate cell growth, development, and stress response.
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Monday, 16 August 2010 17:40 |
Biology faces a basic paradox - life requires DNA to function, yet DNA evolved after life emerged. Now a study of modern bacteria has revealed what DNA's progenitor might be.
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Friday, 03 September 2010 15:22 |
Two new groundbreaking scientific papers by researchers at UC Santa Barbara demonstrate the synthesis of nanosize biological particles with the potential to fight cancer and other illnesses. The studies introduce new approaches that are considered "green" nanobiotechnology because they use no artificial compounds.
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Wednesday, 01 September 2010 15:57 |
Variation in platelet function could hold key to drug development and predictors of disease risk
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Wednesday, 01 September 2010 13:59 |
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Marina Biotech, Inc.,a leading RNAi-based drug discovery and development company, today announced that the U.S. Patent and Trademark Office has issued a Notice of Allowance for patent application U.S. 11/745,003 broadly covering amphoteric liposomal formulations, including the Company's proprietary SMARTICLES(R) technology, for delivery of siRNAs and other compounds with therapeutic application.
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Monday, 30 August 2010 17:03 |
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Micro-ribonucleic acid (miRNA)-199a-5p has been reported to be decreased in hepatocellular carcinoma (HCC) compared to normal tissue. Discoidin domain receptor-1 (DDR1) tyrosine kinase, involved in cell invasion-related signaling pathway, was predicted to be a potential target of miR-199a-5p by the use of miRNA target prediction algorithms.
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Friday, 27 August 2010 15:09 |
UC Davis researchers have received a new, 4-year federal grant to investigate molecular pathways involved in the failure of drugs aimed at slowing prostate cancer.
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Friday, 27 August 2010 13:13 |
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Suited for phenotypic studies, drug discovery applications, or to further studies of microRNA biology, miRIDIAN shMIMIC Lentiviral microRNAs can induce stable over-expression of functional mature microRNA mimics by harnessing endogenous microRNA processing pathway.
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Wednesday, 25 August 2010 17:33 |
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Since last April, 19 cancer patients whose liver tumors hadn’t responded to chemotherapy have taken an experimental drug. Within weeks of the first dose, it appeared to work, by preventing tumors from making proteins they need to survive.
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Monday, 23 August 2010 16:36 |
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We recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ovarian cancer cell line.
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Friday, 20 August 2010 13:41 |
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Colon adenocarcinoma is the leading cause of cancer mortality world-wide and accounts for approximately 50,000 deaths annually in the United States. Adjuvant therapies improve survival for stage III colon cancer patients; however, it remains controversial if stage II patients should be given these therapies.
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Monday, 16 August 2010 15:34 |
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To compare the microRNA (miRNA) expression profiles in neurons and innervated muscles after sciatic nerve entrapment using a non-constrictive silastic tube, subsequent surgical decompression, and denervation injury.
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