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Infectious Disease
New compound defeats drug-resistant bacteria PDF Print E-mail
Tuesday, 29 November 2011 05:07
Jason SelloA new way to attack drug-resistant bacteria: “If drug efflux pumps are inhibited, then bacteria will be susceptible to drugs again.”Chemists at Brown University have synthesized a new compound that makes drug-resistant bacteria susceptible again to antibiotics. The compound — BU-005 — blocks pumps that a bacterium employs to expel an antibacterial agent called chloramphenicol. The team used a new and highly efficient method for the synthesis of BU-005 and other C-capped dipeptides. Results appear in Bioorganic and Medicinal Chemistry.
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Targeting Bacterial Gas Defenses Allow for Increased Efficacy of Numerous Antibiotics PDF Print E-mail
Wednesday, 23 November 2011 04:58

http://www.sciencedaily.com/images/2011/11/111117144009.jpgAlthough scientists have known for centuries that many bacteria produce hydrogen sulfide (H2S) it was thought to be simply a toxic by-product of cellular activity. Now, researchers at NYU School of Medicine have discovered H2S in fact plays a major role in protecting bacteria from the effects of numerous different antibiotics.

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NIH-funded scientists identify potential malaria drug candidates PDF Print E-mail
Friday, 18 November 2011 01:54

New class of compounds would target earliest stages of infection

Researchers have discovered a group of chemical compounds that might one day be developed into drugs that can treat malaria infection in both the liver and the bloodstream. The study, which appears in the Nov. 18 issue of Science, was led by Elizabeth A. Winzeler, Ph.D., of the Scripps Research Institute in La Jolla, Calif., and was partially funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
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Bacterial genes tell the tale of an outbreak's evolution PDF Print E-mail
Monday, 14 November 2011 06:48

Researchers at Harvard Medical School and Children's Hospital Boston have retraced the evolution of an unusual bacterial infection as it spread among cystic fibrosis patients by sequencing scores of samples collected during the outbreak, since contained. A significant achievement in genetic pathology, the work also suggests a new way to recognize adaptive mutations—to see evolution as it happens—and sheds new light on how our bodies resist infection.

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Decrease in observed rate of TB at a time of economic recession PDF Print E-mail
Monday, 07 November 2011 05:17

The incidence of tuberculosis (TB) in the U.S. is reported as being on the decrease, however untreated infected people act as a reservoir for disease. Any pool of the world's population harboring this disease gives cause for concern, especially since the BCG vaccine is only 70-80% effective at best. New research published in BioMed Central's open access journal BMC Public Health, shows that in 2009 the number of cases of TB reported across America was much lower than that recorded in previous years. This larger than expected decrease was most noticeable among recent immigrants, the homeless and other disadvantaged groups, which suggested that the decrease was most likely due to economic recession and lower immigration rates and may mask the future impact of TB.

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Unvaccinated People Affected By Largest Measles Outbreak In Years, USA PDF Print E-mail
Friday, 21 October 2011 20:45
2011 has seen a considerable increase in reported measles cases in Canada and the USA - the vast majority of people who became ill were not vaccinated, informs James M. Hughes, MD, President of the Infectious Disease Society of America. Measles had been declared 'eliminated' in the USA thanks to a high rate of MMR (measles, mumps and rubella) vaccinations among infants.
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Early HIV Treatment Dramatically Increases Survival in Patients Co-Infected With Tuberculosis, Study Suggests PDF Print E-mail
Friday, 21 October 2011 05:33

20111021rfid01Timing is everything when treating patients with both HIV and tuberculosis. Starting HIV therapy in such patients within two weeks of TB treatment, rather than two months as is the current practice, increases survival by 33 percent, according to a large-scale clinical trial in Cambodia led by researchers at Children's Hospital Boston and the Immune Disease Institute (IDI).

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New Acute Hepatitis C Screening Strategy for HIV-Infected Patients PDF Print E-mail
Wednesday, 19 October 2011 01:13

20111019rfid01Researchers at The Miriam Hospital demonstrated a practical strategy for regularly screening HIV-infected patients for acute hepatitis C virus infection (HCV), a "silent epidemic" that is rising undetected in this population and can lead to serious health complications.

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One In Six Mobile Phones In The UK Is Contaminated With Fecal Bacteria PDF Print E-mail
Monday, 17 October 2011 00:55
20111017rfid01Experts say the most likely reason for the potentially harmful bacteria festering on so many gadgets is people failing to wash their hands properly with soap after going to the toilet.
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Secrets Of Disease Outbreaks Revealed By Google Earth Typhoid Maps PDF Print E-mail
Monday, 17 October 2011 00:51
In the mid-nineteenth century, John Snow mapped cases of cholera in Soho, London, and traced the source of the outbreak to a contaminated water pump.
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Scientists determine how antibody recognizes key sugars on HIV surface PDF Print E-mail
Thursday, 24 November 2011 04:13

NIH-led study advances HIV vaccine research

WHAT:

HIV is coated in sugars that usually hide the virus from the immune system. Newly published research reveals how one broadly neutralizing HIV antibody actually uses part of the sugary cloak to help bind to the virus. The antibody binding site, called the V1/V2 region, represents a suitable HIV vaccine target, according to the scientists who conducted the study. In addition, their research reveals the detailed structure of the V1/V2 region, the last part of the virus surface to be visualized at the atomic level.

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Preserving lifesaving antibiotics today and for the future PDF Print E-mail
Friday, 18 November 2011 02:09

Infectious disease experts support 'Get Smart About Antibiotics Week,'

With antibiotic-resistant infections increasingly common, and a dangerous lack of new infection fighters in the drug development pipeline, it's more important than ever to use existing antibiotics appropriately. This week, infectious disease experts are helping to educate consumers, health care providers, and policymakers about when antibiotics can help, when misuse of these lifesaving drugs can do more harm than good, and the tremendous need for new antibiotics to protect patients.

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New study finds that even the cleanest wastewater contributes to more 'super bacteria' PDF Print E-mail
Tuesday, 15 November 2011 05:46

University of Minnesota research suggests that wastewater treated with standard technologies contributes far greater quantities

A new University of Minnesota study reveals that the release of treated municipal wastewater – even wastewater treated by the highest-quality treatment technology – can have a significant effect on the quantities of antibiotic-resistant bacteria, often referred to as "superbacteria," in surface waters.

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Researchers Closer to the Super Bug Puzzle PDF Print E-mail
Saturday, 12 November 2011 06:36

ScienceDaily (Nov. 11, 2011) Infectious diseases specialists from Austin Health are working closely with Microbiologists from the University of Melbourne to understand how Staph is becoming resistant to all antibiotic therapies. 

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Dormant Malaria Parsites in Red Blood Cells May Contribute to Treatment Failure PDF Print E-mail
Tuesday, 25 October 2011 06:23

http://hscweb3.hsc.usf.edu/health/now/wp-content/uploads/LaCrue_Kyle_GHIDR.jpgTampa, FL (Oct. 24, 2011) – Researchers at the University of South Florida (USF) College of Public College Health have shown for the first time in a rodent model that the earliest form of malaria parasites can lay dormant in red blood cells and “wake up,” or recover, following treatment with the antimalarial drug artesunate.

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Drop In Health Care Associated Infections PDF Print E-mail
Friday, 21 October 2011 05:37
According to the Centers for Disease Control and Prevention, four common infections seen in health care facilities declined in 2010.
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Expanding HIV Treatment for Discordant Couples Could Significantly Reduce Global HIV Epidemic PDF Print E-mail
Wednesday, 19 October 2011 01:15

20111019rfid02A new study uses a mathematical model to predict the potential impact of expanding treatment to discordant couples on controlling the global HIV epidemic-- in these couples one partner has HIV infection and the other does not.

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National Latino AIDS Awareness Day 2011 Promotes AIDS Awareness & HIV Testing Nationwide PDF Print E-mail
Monday, 17 October 2011 00:57

Community based organizations, elected officials, community leaders, health departments, Health and Human Services Regions, health educators, advocates and people living with HIV/AIDS call on the importance of HIV testing and the urgent need to respond to the growing HIV/AIDS epidemic among Hispanic/Latino communities nationwide and in Puerto Rico, the US Virgin Islands and the District of Columbia.

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How A Molecular Switch Activates The Anti-Viral Innate Immune Response PDF Print E-mail
Monday, 17 October 2011 00:54
When a thief breaks into a bank vault, sensors are activated and the alarm is raised. Cells have their own early-warning system for intruders, and scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered how a particular protein sounds that alarm when it detects invading viruses.
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Multi-State Listeria Outbreak Deaths Continue PDF Print E-mail
Friday, 14 October 2011 17:14
20111014rfid03The Listeria scare that began with a voluntary recall 14th Sept of Jensen Farms Rocky Ford-brand cantaloupes, and followed with a recall of shredded lettuce, continues to cause deaths, and has now become an economic issue for farms across California with farmers and resellers abandoning the cantaloupes even though they are perfectly safe to eat.
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