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Genomics & Proteomics
Researchers Combine Sequencing, CGH Arrays to Analyze and Annotate a Korean Genome PDF Print E-mail
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Thursday, 09 July 2009 10:34

An international team led by researchers at Seoul National University has sequenced and annotated the genome of a Korean individual — the second Korean genome to be sequenced in recent months and the seventh complete human genome to be published in the past two years.

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Ben-Gurion U. Researchers Reveal Connection Between Cancer and Human Evolution PDF Print E-mail
Thursday, 02 July 2009 10:20

Researchers at Ben-Gurion University of the Negev (BGU) have discovered that gene mutations that once helped humans survive may increase the possibility for diseases, including cancer.

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Little-Known Marine Decomposers Attract the Attention of Genome Sequencers PDF Print E-mail
Monday, 29 June 2009 10:56

http://www.eurekalert.org/multimedia/pub/rel/14974_rel.jpgThe Department of Energy's Joint Genome Institute (JGI) announced today that they will sequence the genomes of four species of labyrinthulomycetes. These little-known marine species were selected for sequencing as the result of a proposal submitted to the competitive JGI Community Sequencing Program by a team of microbiologists led by Dr. Jackie Collier, assistant professor at the School of Marine and Atmospheric Sciences (SoMAS) at Stony Brook University.

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Study Finds LincRNAs Influencing Gene Expression in Human Cells PDF Print E-mail
Thursday, 25 June 2009 10:34
A recently identified group of RNAs called large intergenic non-coding RNAs, or lincRNAs, can influence gene expression, apparently through interactions with chromatin-modifying complexes, according to a paper that's scheduled to appear online this week in the Proceedings of the National Academy of Science.
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Researchers Find New Method for Computing Evolutionary Trees PDF Print E-mail
Monday, 22 June 2009 10:00

http://www.cs.utexas.edu/~tandy/0990-cropped.jpgDetailed, accurate evolutionary trees that reveal the relatedness of living things can now be determined much faster and for thousands of species with a computing method developed by computer scientists and a biologist at The University of Texas at Austin.

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Johns Hopkins Researchers Edit Genes in Human Stem Cells PDF Print E-mail
Thursday, 18 June 2009 09:10

http://www.hopkinsmedicine.org/bin/b/r/ChengPic.jpgResearchers at the Johns Hopkins School of Medicine have successfully edited the genome of human- induced pluripotent stem cells, making possible the future development of patient-specific stem cell therapies. Reporting this week in Cell Stem Cell, the team altered a gene responsible for causing the rare blood disease paroxysmal nocturnal hemoglobinuria, or PNH, establishing for the first time a useful system to learn more about the disease.

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Scientists Identify Gene Vital to Early Embryonic Cells Forming A Normal Heart and Skull PDF Print E-mail
Monday, 15 June 2009 23:52

New research from Cincinnati Children's Hospital Medical Center highlights the critical role a certain gene and its protein play during early embryonic development on formation of a normal heart and skull.

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Good News and Bad for Dad this Father's Day PDF Print E-mail
Sunday, 14 June 2009 16:43

SALT LAKE CITY— It was long believed that conception does not involve a meeting of equals. The egg is a relatively large, impressive biological factory compared with the tiny sperm, which delivers to the egg one copy of the father’s genes.  However, a new study from Huntsman Cancer Institute (HCI) at the University of Utah reveals that the father’s sperm delivers much more complex genetic material than previously thought. The findings could lead to a diagnostic test to help couples deal with infertility.

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Jumping Genes Discovery Challenges Current Assumptions PDF Print E-mail
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Sunday, 14 June 2009 14:53

http://www.med.upenn.edu/camb/faculty/ggr/kazazian.jpgJumping genes do most of their jumping, not during the development of sperm and egg cells, but during the development of the embryo itself. The research, published this month in Genes and Development, "challenges standard assumptions on the timing of when mobile DNA, so-called jumping genes, insert into the human genome," says senior author Haig H. Kazazian Jr., MD, Seymour Gray Professor of Molecular Medicine in Genetics at the University of Pennsylvania School of Medicine.

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Enzyme Necessary For DNA Synthesis Can Also Erase DNA PDF Print E-mail
Wednesday, 10 June 2009 20:38

In this week's edition of Proceedings of the National Academy of Sciences, PNAS, Uppsala University scientists describe a new mechanism behind an important process that causes a rapid reduction of DNA in the chromosomes of bacteria. The findings advance our knowledge of how DNA content has been reduced, which is something that has occurred in bacteria that live as parasites inside the cells of other organisms.

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The GenoMEL Project Identifies a New Region of the Genome Associated With the Risk of Melanoma PDF Print E-mail
Monday, 06 July 2009 08:46

Research is increasingly becoming a networked process. The big genome studies are a good example of the need to pool the efforts of gold standard centers around the world. Only in this way is it possible to achieve results as solid as those obtained by the GenoMEL project, which is funded by the European Commission to study the genetic and environmental risk factors for melanoma. The objective is to translate this knowledge into recommendations based on evidence and healthier habits. The latest results obtained by this project, to published Online on Sunday in the journal Nature Genetics, have found a link between the risk of melanoma and two regions associated with skin pigmentation and a new region of the genome. GenoMEL is led by Leeds University and the IDIBAPS - Hospital Clínic of Barcelona researchers Dr. Susana Puig and Dr. Josep Malvehy are the only Spanish authors of this article.

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Schizophrenia and Bipolar Disorder Share Genetic Roots PDF Print E-mail
Thursday, 02 July 2009 10:18

http://www.eurekalert.org/multimedia/pub/rel/14995_rel.jpgA trio of genome-wide studies – collectively the largest to date – has pinpointed a vast array of genetic variation that cumulatively may account for at least one third of the genetic risk for schizophrenia. One of the studies traced schizophrenia and bipolar disorder, in part, to the same chromosomal neighborhoods.

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New Biomarker Method Could Increase the Number of Diagnostic Tests for Cancer PDF Print E-mail
Monday, 29 June 2009 10:26

http://news.ucsf.edu/images/releases/natureb.jpgA team of researchers, including several from UCSF, has demonstrated that a new method for detecting and quantifying protein biomarkers in body fluids may ultimately make it possible to screen multiple biomarkers in hundreds of patient samples, thus ensuring that only the strongest biomarker candidates will advance down the development pipeline. The researchers have developed a method to increase accuracy in detecting real cancer biomarkers that is highly reproducible across laboratories and a variety of instruments so that cancer can be detected in its earliest stages.

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CSHL Scientists Harness Logic of 'Sudoku' Math Puzzle to Vastly Enhance Genome-Sequencing Capability PDF Print E-mail
Thursday, 25 June 2009 09:33

http://gradschool.cshl.edu/images/09_hannon.gifA math-based game that has taken the world by storm with its ability to delight and puzzle may now be poised to revolutionize the fast-changing world of genome sequencing and the field of medical genetics, suggests a new report by a team of scientists at Cold Spring Harbor Laboratory (CSHL). The report will be published as the cover story in the July 1st issue of the journal Genome Research.

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Genome-wide Map Shows Precisely Where MicroRNAs Do Their Work PDF Print E-mail
Monday, 22 June 2009 09:45

http://newswire.rockefeller.edu/upload/media/061509Darnell.1245084963.jpgMicroRNAs are the newest kid on the genetic block. By regulating the unzipping of genetic information, these tiny molecules have set the scientific world alight with such wide-ranging applications as onions that can’t make you cry and therapeutic potential for new treatments for viral infections, cancer and degenerative diseases. But the question remains: How do they work?

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CHOP-Led Team IDs CNVs Associated With Neuroblastoma PDF Print E-mail
Thursday, 18 June 2009 08:55
In a paper appearing online yesterday in Nature, researchers from the Children's Hospital of Philadelphia and elsewhere reported that they have found germline copy number variations linked to the childhood nervous system cancer neuroblastoma.
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Genomics Study Suggests Sperm Chromatin May Influence Embryo Development PDF Print E-mail
Monday, 15 June 2009 09:06

http://www.huntsmancancer.org/publicweb/content/cairns/images/BradFULL1.jpgThe nature and distribution of chromatin sub-units in the sperm genome may influence embryonic development, according to a study appearing online yesterday in Nature.

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NYU Langone Medical Center Researchers Identify Key Gene in Deadly Inflammatory Breast Cancer PDF Print E-mail
Sunday, 14 June 2009 16:24

Aggressive, deadly and often misdiagnosed, inflammatory breast cancer (IBC) is the most lethal form of primary breast cancer, often striking women in their prime and causing death within 18 to 24 months. Now, scientists from The Cancer Institute at NYU Langone Medical Center have identified a key gene—eIF4G1—that is overexpressed in the majority of cases of IBC, allowing cells to form highly mobile clusters that are responsible for the rapid metastasis that makes IBC such an effective killer.

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JGI Updates Microbial Genomes Resource PDF Print E-mail
Thursday, 11 June 2009 12:58
The US Department of Energy's Joint Genome Institute has released an updated microbial genomics resource for researchers that now includes reference genomes and metagenomic data, JGI said Tuesday.
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Mobile DNA Elements In Woolly Mammoth Genome Give New Clues To Mammalian Evolution PDF Print E-mail
Wednesday, 10 June 2009 20:35

http://www.sciencedaily.com/images/2008/11/081119140712-thumb.jpgThe woolly mammoth died out several thousand years ago, but the genetic material they left behind is yielding new clues about the evolution of mammals. In a study published online in Genome Research, scientists have analyzed the mammoth genome looking for mobile DNA elements, revealing new insights into how some of these elements arose in mammals and shaped the genome of an animal headed for extinction.

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