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Genomics & Proteomics
WashU Team Publishes Second AML Genome PDF Print E-mail
Friday, 07 August 2009 06:06
In a paper appearing online today in the New England Journal of Medicine, researchers from Washington University have published results from the second sequenced acute myeloid leukemia genome.
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Scripps Research scientists find early evolution maximized the 'spellchecking' of protein sequences PDF Print E-mail
Friday, 07 August 2009 06:00

As letters of the alphabet spell out words, when amino acids are linked to one another in a particular order they "spell out" proteins. But sometimes the cell machinery for building proteins in our bodies makes a mistake and the wrong amino acid is inserted. The consequences can be devastating, resulting in a garbled protein that no longer has the correct function, possibly leading to cancers and other diseases.

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Decoding Leukemia Patient Genome Leads Scientists To Mutations In Other Patients PDF Print E-mail
Wednesday, 05 August 2009 21:26

Decoding the complete DNA of cancer patients is giving scientists at Washington University School of Medicine in St. Louis a clearer picture of the complexity of the disease and allowing them to see intriguing and unexpected genetic relationships among patients.

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Phylogenetic Study Finds Human Malaria Originated In Chimps PDF Print E-mail
Wednesday, 05 August 2009 04:47
Based on their phylogenetic analysis, an international research team has concluded that the human malaria parasite Plasmodium falciparum originated from P. reichenowi, a species carried by chimpanzees.
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African village dogs are genetically much more diverse than modern breeds PDF Print E-mail
Wednesday, 05 August 2009 04:40

African village dogs are not a mixture of modern breeds but have directly descended from an ancestral pool of indigenous dogs, according to a Cornell-led genetic analysis of hundreds of semi-feral African village dogs.

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Variation in prostate stem cell antigen gene raises bladder cancer risk PDF Print E-mail
Monday, 03 August 2009 09:35

HOUSTON - Researchers have pinpointed a specific gene variation that causes increased risk of urinary bladder cancer, according to a scientific team led by The University of Texas M. D. Anderson Cancer Center.

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Unlocking the key to human fertility PDF Print E-mail
Monday, 03 August 2009 09:27

Scientists at Leeds and Bradford have discovered a unique 'DNA signature' in human sperm, which may act as a key that unlocks an egg's fertility and triggers new life.

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Genetic Link To Age-related Cataracts Uncovered PDF Print E-mail
Friday, 31 July 2009 03:49

Bing-Cheng Wang, Ph.D., Case Western Reserve University School of Medicine professor of pharmacology and senior staff scientist at MetroHealth Medical Center, and Sudha K. Iyengar, Ph.D. professor of genetic and molecular epidemiology at Case Western Reserve University School of Medicine, have discovered the first gene associated with the formation of age-related cataracts, a leading causes of blindness.

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Reef Genomics PDF Print E-mail
Friday, 31 July 2009 02:56

Australian scientists have announced that they will be mapping the genome of Acropora millepora, the dominant coral of the Great Barrier Reef, reports Agence France Presse.

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Genetics Suggest Population Expansion in Africa Began in Stone Age PDF Print E-mail
Thursday, 30 July 2009 03:36
Modern human populations started expanding some 40,000 years ago, according to a paper appearing appeared online today in PLoS ONE.
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Penn State Team IDs Expression Changes Linked To Drug Relapse in Rats PDF Print E-mail
Friday, 07 August 2009 06:03
A team of researchers from Pennsylvania State University has identified dozens of genes whose expression in rat brains changes in concert with drug relapse behavior in heroin-addicted animals.
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Carnegie Mellon develops innovative method to detect genetic causes of complex diseases PDF Print E-mail
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Friday, 07 August 2009 05:55
Computational biologists at Carnegie Mellon University have developed an analytical technique to detect the multiple genetic variations that contribute to complex disease syndromes such as diabetes, asthma and cancer, which are characterized by multiple clinical and molecular traits.
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Structure Of An Entire HIV Genome Decoded PDF Print E-mail
Wednesday, 05 August 2009 19:03

The structure of an entire HIV genome has been decoded for the first time by researchers at the University of North Carolina at Chapel Hill. The results have widespread implications for understanding the strategies that viruses, like the one that causes AIDS, use to infect humans.

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Protein complex key in avoiding DNA repair mistakes, cancer PDF Print E-mail
Wednesday, 05 August 2009 04:46

ANN ARBOR, Mich. As the body creates antibodies to fight invaders, a three-protein DNA repair complex called MRN is crucial for a normal gene-shuffling process to proceed properly, University of Michigan research shows.

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Clark Atlanta Starting Cancer Genomics Center with GT PDF Print E-mail
Wednesday, 05 August 2009 04:38
Clark Atlanta University tomorrow will publicly launch its Collaborative Cancer Genomics Center, a collaboration with the Georgia Institute of Technology and St. Joseph's Hospital in Atlanta that was funded with federal and regional public and private funds.
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Gene Variation that Increases Urinary Bladder Cancer Risk Discovered PDF Print E-mail
Monday, 03 August 2009 09:30

A specific gene variation in the prostate stem cell antigen (PSCA) gene causes a 30% to 40% higher risk for urinary bladder cancer, according to a scientific team led by The University of Texas M. D. Anderson Cancer Center. They say that the rs2294008 variant was associated consistently with the disease and was found to be the only common missense genetic variation in the PSCA gene region.

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Synthetic Biology: Opportunities And Risks PDF Print E-mail
Monday, 03 August 2009 09:08

The new research field of synthetic biology will, in the medium term, open up a great deal of potential for combining novel genetic methods with engineering principles. This will facilitate the development, not only of new vaccines and medicines, but also of fuels and new materials.

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Mutation responsible for cystic fibrosis also involved in muscle atrophy PDF Print E-mail
Friday, 31 July 2009 03:10

Montreal, July 30, 2009 Patients with cystic fibrosis (CF) usually experience significant muscle loss, a symptom traditionally considered to be a secondary complication of the devastating genetic disease. However, a recent study by Dr. Basil Petrof reverses the equation: his results show that muscle atrophy and weakness may be a primary symptom caused by the effects of CFTR gene mutations on the muscle itself. Dr. Petrof's findings will be published on July 31 in Public Library of Science Genetics.

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Team IDs Cell Type-Specific Expression Effects for Regulatory Variants PDF Print E-mail
Friday, 31 July 2009 02:55
Up to 80 percent of regulatory variants appear to operate in a cell type-specific way, according to a paper appearing in the advanced, online edition of Science today.
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U of Queensland Adds Nine ABI SOLiD Systems PDF Print E-mail
Thursday, 30 July 2009 03:24
Researchers at the University of Queensland will add nine new sequencing systems from Applied Biosystems to its labs in order to support its efforts in the International Cancer Genome Consortium.
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