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Genomics & Proteomics
BGI-Shenzhen to Lead Microbial Genome Encyclopedia Project PDF Print E-mail
Monday, 17 August 2009 05:58

The Beijing Genomics Institute-Shenzhen will lead a project with other Chinese Universities that will begin development of a genomic encyclopedia of microbes that exist in China.The "Ten Thousand Microbial Genomes Project" will serve as a companion of the international 1000 Genomes Project, and will "focus on the systematic research of highly diversified microbial resources in China at the genome level," BGI-Shenzhen said recently.

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Muscular Protein Bond -- Strongest Yet Found In Nature PDF Print E-mail
Friday, 14 August 2009 04:23

A research collaboration between Munich-based biophysicists and a structural biologist in Hamburg is helping to explain why our muscles, and those of other animals, don't simply fall apart under stress. Their findings may have implications for fields as diverse as medical research and nanotechnology. The real strength of any skeletal muscle doesn't start with exercise; it comes ultimately from nanoscale biological building blocks. One key element is a bond involving titin, a giant among proteins. Titin is considered a molecular "ruler" along which the whole muscle structure is aligned, and it acts as an elastic spring when a muscle is stretched.

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New gene linked to muscular dystrophy PDF Print E-mail
Friday, 14 August 2009 03:37

Muscular dystrophy, a group of inherited diseases characterized by progressive skeletal muscle weakness, can be caused by mutations in any one of a number of genes. Another gene can now be added to this list, as Yukiko Hayashi and colleagues, at the National Center of Neurology and Psychiatry, Japan, have now identified mutations in a gene not previously linked to muscular dystrophy as causative of a form of the disease in five nonconsanguineous Japanese patients.

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Discovery of genetic mutation in Leigh syndrome PDF Print E-mail
Friday, 14 August 2009 03:25

Researchers at the Montreal Neurological Institute and Hospital (The Neuro), McGill University have discovered a genetic mutation underlying late-onset Leigh syndrome, a rare inherited metabolic disorder characterized by the degeneration of the central nervous system. The study published in Nature Genetics, provides vital insights into the cell biology of this neurological disorder and will lead to the development of diagnostic and predictive tests allowing for family and genetic counseling.

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Raising The Alarm When DNA Goes Bad: 'Rapid Response Team' Monitors And Quickly Responds To DNA Damage PDF Print E-mail
Friday, 14 August 2009 02:32

Our genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases. Scientists have known for a long time that when DNA is damaged, a key enzyme sets off a cellular ‘alarm bell’ to alert the cell to start the repair process, but until recently little was known about how the cell detects and responds to this alarm.

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Metabonomic Profiling Provides Drug Metabolism Clues PDF Print E-mail
Wednesday, 12 August 2009 05:59
British researchers reported this week that metabolic profiling of urine samples prior to drug treatment could help predict an individual's response to the drug."Even for this most familiar drug, pharmacometabonomic analysis will yield significantly increased understanding of its metabolic behavior in humans," the researchers wrote. "These findings have considerable implications for personalized drug treatment in general and lead to new and testable hypotheses for a number of diseases."
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Scripps Starts Genomics Study of Breast Cancer Variants PDF Print E-mail
Wednesday, 12 August 2009 05:42
Scripps Genomic Medicine will work with Scripps Memorial Hospital La Jolla to conduct genomic studies of women for known variants of breast cancer in order to correlate the presence of variants with diagnosis of the disease, Scripps Genomic Medicine said. The PINK study, which is funded by the Scripps Research Institute, aims to enroll 3,500 women who are receiving screenings at the Scripps Polster Breast Care Center who have had at least five years of breast imaging records available, and who will undergo a DNA analysis.
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Function Of Potential Cancer-Causing Gene Product Uncovered By Conaway Lab PDF Print E-mail
Monday, 10 August 2009 06:11
The Stowers Institute's Conaway Lab has uncovered a previously unknown function of a gene product called Amplified in Liver Cancer 1 (Alc1), which may play a role in the onset of cancer. The work is published in the Proceedings of the National Academy of Science Early Edition.
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University Of The Basque Country Researcher Studies Genes Associated With Celiac Disease PDF Print E-mail
Monday, 10 August 2009 06:08
For her PhD thesis, the researcher studied the genetic profiles of 175 cases of patients suffering from celiac illness, in order to determine which genes are related to the disease and to study diagnostic methods.
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Potential Mechanisms To Protect Against Genetic Alterations, Diseases, Uncovered By Researchers PDF Print E-mail
Monday, 10 August 2009 05:58
Peering into the DNA of tiny yeast, researchers at the Moores Cancer Center at the University of California, San Diego and the San Diego Branch of the Ludwig Institute for Cancer Research have pinpointed a large number of genes that can prevent a type of genetic rearrangement that may lead to cancer and other diseases.
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Protein Plays Unexpected Role Protecting Chromosome Tips PDF Print E-mail
Friday, 14 August 2009 04:28

HOUSTON - A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destruction complex, a team lead by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Aug. 13 edition of Molecular Cell.

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First Human Gene Implicated In Regulating Length Of Human Sleep PDF Print E-mail
Friday, 14 August 2009 03:38

Scientists have discovered the first gene involved in regulating the optimal length of human sleep, offering a window into a key aspect of slumber, an enigmatic phenomenon that is critical to human physical and mental health. The team, reporting in the Aug. 14, 2009 issue of Science, identified a mutated gene that allows two members of an extended family to thrive on six hours of sleep a day rather than the eight to eight-and-a-half hours that studies have shown humans need over time to maintain optimal health. Working from this discovery, the scientists genetically engineered mice and fruit flies to express the mutated gene and study its impact.

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Scientists discover new Alzheimer's gene PDF Print E-mail
Friday, 14 August 2009 03:31
A UC Irvine study has found that a gene called TOMM40 appears twice as often in people with Alzheimer's disease than in those without it. Alzheimer's, for which there is no cure, is the leading cause of elderly dementia.Having the harmful form of TOMM40 significantly increases one's susceptibility when other risk factors - such as having a gene called ApoE-4 - are present, the new study reports. People who have ApoE-4 are three to eight times more likely to develop Alzheimer's.
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State Laws Could Cover DTC Gene Testing PDF Print E-mail
Friday, 14 August 2009 02:38
While the US government considers whether or not it will draft policies to regulate the marketing of direct-to-consumer genetic testing through panels and working groups, the Genetics and Public Policy Center at Johns Hopkins University has taken a look at state laws to find out if they would cover such advertising.
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Magnetic Microbe Genome Attracting Attention For Biotech Research PDF Print E-mail
Thursday, 13 August 2009 04:24

The smallest organisms to use a biological compass are magnetotactic bacteria, however mysteries remain about exactly how these bacteria create their cellular magnets. In a study published online in Genome Research, scientists have used genome sequencing to unlock new secrets about these magnetic microbes that could accelerate biotechnology and nanotechnology research.

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Stanford Team Sequences Human Genome Using Helicos Technology PDF Print E-mail
Wednesday, 12 August 2009 05:50
Scientists from Stanford University reported online today in Nature Biotechnology that they have sequenced the genome of a Caucasian man using a Helicos Biosciences Heliscope single molecule sequencer. Stanford University bioengineer and Helicos Co-founder Stephen Quake, who now chairs the company's scientific advisory board, sequenced his own genome — using a single Heliscope machine and four data collection runs — with help from two members of his lab: graduate student Dmitry Pushkarev and research technical manager Norma Neff.
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NCGR to Use febit Technology in Resequencing Initiative Covering 400 Childhood Diseases PDF Print E-mail
Wednesday, 12 August 2009 05:02
The National Center for Genome Resources (NCGR) elected to use febit’s automated HybSelect™ DNA sequence capture technology for a gene resequencing program it hopes will ultimately lead to the development of tests for identifying recessive genetic diseases in prospective parents. Based on the Geniom RT Analyzer platform, the automated HybSelect technology will be used to capture specific exons of interest for resequencing using Illumina next-generation sequencing technology.
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Tumor Mutations Can Predict Chemo Success - Genetic Profiling Of Tumors Could Have 'immediate Impact' On Treating Cancer, Study Shows PDF Print E-mail
Monday, 10 August 2009 06:10
New work by MIT cancer biologists shows that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy.
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Underlying Viral Infection Identied By Genomic Signature In Blood PDF Print E-mail
Monday, 10 August 2009 06:03
Scientists have identified a genomic "signature" in circulating blood that reveals exposure to common upper respiratory viruses, like the cold or flu, even before symptoms appear. The tell-tale viral signature reflects a set of subtle but robust changes in genes that are activated as the body responds to infection. The signal from the signature is strong enough in symptomatic individuals to clearly reveal whether their infection is viral or bacterial. It can also discriminate between who has a viral infection and who does not - all from a single tube of blood.
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International Team Develops Corn Genetics Resource PDF Print E-mail
Friday, 07 August 2009 06:13
An international research team has developed a new resource for mapping the genetics underlying complex traits in corn.
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