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Genomics & Proteomics
New Method Developed To Detect Copy Number Variants Using DNA Sequencing Technologies PDF Print E-mail
Wednesday, 26 August 2009 00:34

A research team led by Associate Professor Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL) has developed a sensitive and accurate way of identifying gene copy number variations (CNVs). The method, which is described in a paper published online ahead of print in Genome Research, uses new DNA sequencing technologies to look for regions of the genome that vary in copy number between individuals in the population.

Gene Variant Linked To Effectiveness Of Popular Anti-clotting Medication Plavix PDF Print E-mail
Tuesday, 25 August 2009 23:47

Researchers at the University of Maryland School of Medicine have identified a common gene variant carried by as many as a third of the general population that is believed to play a major role in determining why people do not respond to a popular anti-clotting medication, Plavix. If the medication doesn't work, patients are at increased risk for subsequent heart attacks, strokes and other serious cardiovascular problems.

10th Functional Genomics: Chemical Biology 2009 PDF Print E-mail
Monday, 24 August 2009 05:06
A cure for cystic fibrosis, HIV-fighting 'Trojan horses', new pharmaceuticals from the ocean. Chemical biologists use new and innovative approaches to discover medications of the future. On 24 August, some of the field's most prominent researchers will attend an international conference in Gothenburg, Sweden.
Sequencing Suggests Intestinal Parasite May Be Two Species PDF Print E-mail
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Sunday, 23 August 2009 21:44
The Giardia intestinalis parasite behind the human intestinal disease giardiasis may actually be two species, according to a paper appearing online today in PLoS Pathogens on the draft genome sequence of a G. intestinalis strain from the assemblage B genotype. The team used Roche 454 sequencing to sequence the genome of a G. intestinalis isolate called GS, which belongs to the "B" G. intestinalis genotype. When they compared the GS draft genome to that of an isolate called WB from the "A" genotype, the researchers discovered a slew of differences between the two isolates.
Signature Genomic Laboratories Named to 2009 Inc. 5000 with Three-Year Sales Growth of 302.9% PDF Print E-mail
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Friday, 21 August 2009 04:05

Inc. magazine ranked Signature Genomic Laboratories no. 1012 on its third annual Inc. 5000, an exclusive ranking of the nation's fastest-growing private companies. The company, which performs microarray-based diagnostic genetic testing of chromosome abnormalities in individuals with unexplained mental retardation and/or birth defects, experienced three-year sales growth of 302.9%, more than twice that of the Inc. 5000 industry median and over 12 times the industry benchmark. Signature was also ranked 70th of companies in the healthcare sector.

Researchers Confirm That Genes Increase Risk Of Lung Cancer In Smokers PDF Print E-mail
Friday, 21 August 2009 03:56
UK researchers who searched the DNA of over 5,000 smokers and non-smokers have found more evidence that inherited genes can increase a smoker's risk of developing lung cancer and also decide the type of cancer that develops. The study was the work of researchers from the Institute of Cancer Research and is published in the 15 August issue of Cancer Research. The lead author was Professor Richard Houlston, a Cancer Research UK funded scientist at The Institute of Cancer Research.
Anti-aging gene linked to high blood pressure PDF Print E-mail
Thursday, 20 August 2009 04:02

OKLAHOMA CITY Researchers at the University of Oklahoma Health Sciences Center have shown the first link between a newly discovered anti-aging gene and high blood pressure. The results, which appear this month in the journal Hypertension, offer new clues on how we age and how we might live longer. Persistent hypertension, or high blood pressure, is a risk factor for stroke, heart attack, heart failure, arterial aneurysm and is the leading cause of chronic kidney failure. Even a modest elevation of arterial blood pressure leads to shortened life expectancy.

New reagents for genomic engineering of mouse models to understand human disease PDF Print E-mail
Wednesday, 19 August 2009 04:12

The ability to specifically target and modify genes in the mouse allows researchers to use this small rodent to study how certain genes contribute to human disease. A common method used to make genetic changes in mice and cells is called site-specific recombination, where two DNA strands are exchanged. The two strands may contain very different sequences, but are designated at their ends by specific target sequences that are not commonly found elsewhere in the genome.

CDC/NIH Workshop Releases Personal Genomics Recommendations PDF Print E-mail
Monday, 17 August 2009 06:27
A government-led panel has issued a list of recommendations related to the clinical utility and clinical validity of personal genomic tests, enhancing knowledge about these tests, and developing standards for these tests, according to a report in the journal Genetics in Medicine. The report is the product of a December 2008 workshop led by the National Institutes of Health and the Centers for Disease Control and Prevention, and it included a number of other stakeholders in government, academia, and the business world.
New biomarker predicts response to hepatitis C treatment PDF Print E-mail
Monday, 17 August 2009 06:17

DURHAM, N.C. Researchers have identified the first genetic marker that predicts response to hepatitis C treatments, and a single letter of DNA code appears to make a huge difference. Duke University Medical Center scientists says the biomarker not only predicts who is most likely to respond to treatment and who isn't, but also may explain why there are such different rates of response among racial and ethnic groups, a phenomenon that has puzzled physicians for years.

Bee Gene Expression Study Yields Marker for Colony Collapse Disorder PDF Print E-mail
Wednesday, 26 August 2009 00:10
Honey bees from colonies affected by colony collapse disorder, or CCD, harbor ribosomal RNA fragments that may be useful for early CCD detection, according to a study appearing online this week in the Proceedings of the National Academy of Sciences.
Genome BC Leading $8M Tree Genomics Program PDF Print E-mail
Tuesday, 25 August 2009 04:05
The Canadian government through Genome British Columbia and several other organizations will grant C$8.8 million ($8.2 million) for genomics research that will support the BC Bioenergy Strategy, which calls for increasing production of renewable biofuels in ways that do not compete with food supplies, Genome BC said.
An Inner 'Fingerprint' For Personalizing Medical Care PDF Print E-mail
Monday, 24 August 2009 05:01

Fingerprints move over. Scientists are reporting evidence that people have another defining trait that may distinguish each of the 6.7 billion humans on Earth from one another almost as surely as the arches, loops, and whorls on their fingertips. They report evidence from studies in humans for the existence of unique patterns in metabolism.

Genomics Could be Key to Protecting Canada's Forests PDF Print E-mail
Sunday, 23 August 2009 21:41
Genomics could play an important role in Canada's efforts to manage and protect its forests, including protecting them from pests, plants, and climate change, according to a new report from a Canadian government-funded initiative. The report recommends launching five large-scale forest genomics projects, and funding them with between C$5 million ($4.6 million) and C$10 million.
Housekeeping Gene Study Impacts Lesch Nyhan & Parkinson's PDF Print E-mail
Friday, 21 August 2009 03:59
A study from the Center for Molecular Genetics at the University of California, San Diego School of Medicine shows that a gene called HPRT plays an important role in setting the program by which primitive or precursor cells decide to become normal nerve cells in the human brain. This unconventional view of metabolic genes known as "housekeeping" genes is now online at the journal Molecular Therapy.
JCVI Employs Yeast as Go-Between in Bacterial Genome Transplant PDF Print E-mail
Friday, 21 August 2009 03:49
Researchers from the J. Craig Venter Institute demonstrated online in Science today that they were again able to transplant the genome of one bacterial species into another — this time with a brief stopover in yeast. The team cloned the Mycoplasma mycoides genome into a yeast centromeric vector and transformed it into yeast, where they tweaked the sequence before transplanting it into M. capricolum.
Mutation In Renin Gene Linked To Inherited Kidney Disease PDF Print E-mail
Wednesday, 19 August 2009 04:17
A mutation in a gene that helps regulate high blood pressure is a cause of inherited kidney disease, according to a new study by researchers at Wake Forest University School of Medicine, Charles University in Prague and colleagues.The discovery provides insight into a protein, renin, that is important in blood pressure regulation, and reveals the cause of one type of inherited kidney disease occurring in adults and children, said co-investigator Anthony Bleyer, M.D., professor of internal medicine-nephrology at the School of Medicine.
Scripps Research, UCSD, and University of Oslo team ties genetic variations to brain size PDF Print E-mail
Wednesday, 19 August 2009 04:03
Using advanced brain imaging and genomics technologies, an international team of researchers co-led by Scripps Research Institute scientists has shown for the first time that natural variations in a specific gene influence brain structure. By establishing this link, the researchers have opened the door to a range of potential research efforts that could reveal gene variations responsible for a number of neurological conditions such as autism. The work was reported in an advance, online Early Edition of the Proceedings of the National Academy of Sciences (PNAS) the week of August 17, 2009.
Study Finds Polyploidy Relatively Common Plant Speciation Mechanism PDF Print E-mail
Monday, 17 August 2009 06:22
About four times as many vascular plant speciation events as previously believed involved an increase in polyploidy, according to an early online paper in the Proceedings of the National Academy of Sciences this week.
Canadian Team Publishes Proof-Of-Principle Paper Using Boreal Genomics Technology PDF Print E-mail
Monday, 17 August 2009 06:08
Researchers from the University of British Columbia and the Michael Smith Genome Sciences Centre in Vancouver have published a proof-of-principle study demonstrating the use of their electric field-based method for extracting DNA from contaminated material.
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