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Genomics & Proteomics
Outside influence: Genes outside nucleus have disproportionate effect PDF Print E-mail
Saturday, 12 October 2013 22:15

New research from the University of California, Davis, shows that the tiny proportion of a cell's DNA that is located outside the cell nucleus has a disproportionately large effect on a cell's metabolism. The work, with the model plant Arabidopsis, may have implications for future treatments for inherited diseases in humans.

Oncogenic signatures mapped in TCGA a guide for the development of personalized therapy PDF Print E-mail
Sunday, 29 September 2013 17:08

New York, September 27, 2013 -- Clinical trial design for new cancer therapies has historically been focused on the tissue of origin of a tumor, but a paper from researchers at Memorial Sloan-Kettering Cancer Center published on September 26 in Nature Genetics supports a new approach: one based on the genomic signature of a tumor rather than the tissue of origin in the body.

Unprecedented control of genome editing in flies promises insight into human development, disease PDF Print E-mail
Saturday, 24 August 2013 16:01

MADISON — In an era of widespread genetic sequencing, the ability to edit and alter an organism's DNA is a powerful way to explore the information within and how it guides biological function.

A paper from the University of Wisconsin–Madison in the August issue of the journal GENETICS takes genome editing to a new level in fruit flies, demonstrating a remarkable level of fine control and, importantly, the transmission of those engineered genetic changes across generations.

Gene mutation in dogs offers clues for neural tube defects in humans PDF Print E-mail
Saturday, 20 July 2013 22:25

A gene related to neural tube defects in dogs has for the first time been identified by researchers at the University of California, Davis, and University of Iowa.

Scientists explore the mind with epigenomic maps PDF Print E-mail
Saturday, 06 July 2013 16:13

A neuron matrixComprehensive mapping of the human brain epigenome by UWA and US scientists uncovers large-scale changes that take place during the formation of brain circuitry. 

Ground-breaking research by scientists from The University of Western Australia and the US, published this week in Science, has provided an unprecedented view of the epigenome during brain development. 

High-resolution mapping of the epigenome has discovered unique patterns that emerge during the generation of brain circuitry in childhood. 

The genome sequence of Tibetan antelope sheds new light on high-altitude adaptation PDF Print E-mail
Saturday, 18 May 2013 06:18

May 17, 2013, Shenzhen, China---- Why Tibetan antelope can live at elevations of 4,000-5,000m on the Qinghai-Tibetan Plateau? In a collaborative research published in Nature Communications, investigators from Qinghai University, BGI, and other institutes provide evidence that some genetic factors may be associated with the species' adaption to harsh highland environments. The data in this work will also provide implications for studying specific genetic mechanisms and the biology of other ruminant species.

Genome study suggests new strategies for understanding and treating pulmonary fibrosis PDF Print E-mail
Sunday, 21 April 2013 05:49

A new genome-wide association study of more than 6,000 people has identified seven new genetic regions associated with pulmonary fibrosis. In findings published online in Nature Genetics on April 14, 2013, researchers at National Jewish Health, the University of Colorado and several other institutions found a number of genes associated with host defense, cell-cell adhesion and DNA repair, which provide clues to possible mechanisms underlying this currently untreatable disease.

When will genomic research translate into clinical care -- and at what cost? PDF Print E-mail
Sunday, 06 January 2013 03:35

New study applies quantitative modeling to genomics

BOSTON – Genomic research is widely expected to transform medicine, but progress has been slower than expected. While critics argue that the genomics "promise" has been broken – and that money might be better spent elsewhere -- proponents say the deliberate pace underscores the complexity of the relationship between medicine and disease and, indeed, argues for more funding.

Genes linked to low birth weight, adult shortness and later diabetes risk PDF Print E-mail
Sunday, 02 December 2012 13:47

Researchers at The Children's Hospital of Philadelphia part of a large international study

An international team of genetics researchers has discovered four new gene regions that contribute to low birth weight. Three of those regions influence adult metabolism, and appear to affect longer-term outcomes such as adult height, risk of type 2 diabetes and adult blood pressure.

Skin cells reveal DNA's genetic mosaic PDF Print E-mail
Monday, 19 November 2012 01:04

The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening, according to Yale School of Medicine researchers.

Largest, most accurate list of RNA editing sites PDF Print E-mail
Sunday, 29 September 2013 17:20

PROVIDENCE, R.I. [Brown University] — A research team centered at Brown University has compiled the largest and most stringently validated list of RNA editing sites in the fruit fly Drosophilamelanogaster, a stalwart of biological research. Their research, which yielded several insights into the model organism's fundamental biology, appears Sept. 29 in Nature Structural & Molecular Biology.

Balancing Act: Cell Senescence, Aging Related to Epigenetic Changes PDF Print E-mail
Saturday, 31 August 2013 06:25

Penn study links epigenetics, aging, mutations in nuclear proteins to better understand cancer, rare disorders.

PHILADELPHIA – One way cells promote tumor suppression is through a process called senescence, an irreversible arrest of proliferation. Senescence is thought to be associated with normal aging, but is also a protective measure by the body against run-away cell replication. Studying the basic science of senescence gives biomedical researchers a better understanding of the mechanisms behind age-related diseases such as cancer.

Gene combinations and interactions affect risk of Crohn's disease PDF Print E-mail
Saturday, 24 August 2013 15:58

Model including dozens of mutations helps clarify genetic factors involved in Crohn's disease

Philadelphia, Pa. (August 22, 2013) – A statistical model accounting for dozens of different genes in combination—and the interactions between them—is an important step forward in understanding the genetic factors affecting the risk of Crohn's disease (CD), reports a study in Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA). The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

U of M researchers identify new functions for autoimmune disease 'risk' gene PDF Print E-mail
Saturday, 20 July 2013 22:19

Work could have big impact on autoimmune disease treatment strategies

MINNEAPOLIS/ST. PAUL (July 19, 2013) – Researchers at the University of Minnesota have identified infection-fighting and inflammation-suppressing functions for a gene associated with human autoimmune disease.

Common genetic disease linked to father's age PDF Print E-mail
Saturday, 08 June 2013 22:58

Genetic mutation of a testis stem cell actually gives the disease an edge, making older fathers more likely to pass it along to their children

Scientists at USC have unlocked the mystery of why new cases of the genetic disease Noonan Syndrome are so common: a mutation that causes the disease disproportionately increases a normal father's production of sperm carrying the disease trait.

Sacred lotus genome sequence enlightens scientists PDF Print E-mail
Friday, 10 May 2013 23:14

CHAMPAIGN, Ill. — The sacred lotus (Nelumbo nucifera) is a symbol of spiritual purity and longevity. Its seeds can survive up to 1,300 years, its petals and leaves repel grime and water, and its flowers generate heat to attract pollinators.

The new age of proteomics: An integrative vision of the cellular world PDF Print E-mail
Saturday, 19 January 2013 16:50

The head of CNIO's Proteomics Core Unit, Javier Munoz, working alongside Dutch researchers, revises the technology of the post-genomic age and its contributions to the advance of biomedicine

The first goat genome sets a good example for facilitating de novo assembly of large genomes PDF Print E-mail
Wednesday, 26 December 2012 18:18

December 23, 2012, Shenzhen, China – In a collaborative study published online today in Nature Biotechnology, researchers from Kunming Institute of Zoology, Chinese Academy of Sciences, BGI, and other institutes, have completed the first genome sequence of domestic goat by a robust approach integrated with next-generation sequencing (NGS) and whole-genome mapping (WGM) technologies. The goat genome is the first reference genome for small ruminant animals and may help to advance the understanding of distinct ruminants' genomic features from non-ruminant species. This work also yields a valuable experience for facilitating the de novo assemblies of large, complex genomes in the future.

Short DNA strands in the genome may be key to understanding human cognition and diseases PDF Print E-mail
Saturday, 24 November 2012 13:37

Previously discarded, human-specific 'junk' DNA represents untapped resource in the study of diseases like Alzheimer's and autism

Short snippets of DNA found in human brain tissue provide new insight into human cognitive function and risk for developing certain neurological diseases, according to researchers from the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. The findings are published in the November 20th issue of PLoS Biology.

BUSM study investigates genetic variants' role in increasing Parkinson's disease risk PDF Print E-mail
Sunday, 07 October 2012 21:50

(Boston) – Boston University School of Medicine (BUSM) investigators have led the first genome-wide evaluation of genetic variants associated with Parkinson's disease (PD). The study, which is published online in PLOS ONE, points to the involvement of specific genes and alterations in their expression as influencing the risk for developing PD.

Jeanne Latourelle, DSc, assistant professor of neurology at BUSM, served as the study's lead author and Richard H. Myers, PhD, professor of neurology at BUSM, served as the study's principal investigator and senior author.

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