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Cancer Research
Study finds gaps in 'decision aids' designed to help determine right cancer screening option PDF Print E-mail
Friday, 10 May 2013 22:58

With a focus on shared decision making between doctors and patients, more studies needed to determine how decision aids help guide choices for cancer screening.

ANN ARBOR, Mich. — When it comes to a cancer diagnosis, timing can be everything – the sooner it's found, the more treatable it is. But when and how often should someone get screened?

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CWRU School of Medicine researchers discover new target for personalized cancer therapy PDF Print E-mail
Sunday, 05 May 2013 00:37

A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine have developed a novel method to disrupt this growth signaling pathway, with findings that suggest a new treatment for breast, colon, melanoma and other cancers.

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GW Cancer Institute Publishes Research on Challenges Faced by Adolescent and Young Adult Cancer Survivors PDF Print E-mail
Sunday, 28 April 2013 21:58

WASHINGTON (April 26, 2013) – New research out of the George Washington University Cancer Institute (GWCI) focuses on the difficulties of transitioning to adulthood while dealing with the long-term and late effects of cancer and its treatment. The study was recently published in the Journal of Oncology Navigation and Survivorship, titled “Improving Cancer Survivorship for Adolescents and Adults.”

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Battery of tests on cancer cells shows them as 'squishy,' yet tactically strong PDF Print E-mail
Sunday, 28 April 2013 21:37

Student researchers get a new view of the dynamics of cancer cells as they metastasize

TEMPE, Ariz. – A team of student researchers and their professors from 20 laboratories around the country have gotten a new view of cancer cells. The work could shed light on the transforming physical properties of these cells as they metastasize, said Jack R. Staunton, a Ph.D. candidate at Arizona State University in the lab of Prof. Robert Ros, and the lead author of a paper reporting on the topic.

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2 landmark studies report on success of using image-guided brachytherapy to treat cervical cancer PDF Print E-mail
Sunday, 21 April 2013 06:04

Geneva, Switzerland: Two large, landmark radiotherapy studies have shown that it is possible to treat cervical cancer effectively with high doses specifically adapted to each tumour, and with fewer serious side-effects to the surrounding normal organs.

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Novel monoclonal antibody inhibits tumor growth in breast cancer and angiosarcoma PDF Print E-mail
Sunday, 21 April 2013 05:46

CHAPEL HILL, N.C. - A monoclonal antibody targeting a protein known as SFPR2 has been shown by researchers at the University of North Carolina to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma.

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2-step ovarian cancer immunotherapy made from patients' own tumor shows promise PDF Print E-mail
Saturday, 06 April 2013 16:55

Trial benefits three-quarters of patients

WASHINGTON, D.C. — As many as three quarters of advanced ovarian cancer patients appeared to respond to a new two-step immunotherapy approach -- including one patient who achieved complete remission -- according research from the Perelman School of Medicine at the University of Pennsylvania that will be presented today in a press conference at the AACR Annual Meeting 2013 (Presentation #LB-335).

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Smoking immediately upon waking may increase risk of lung and oral cancer PDF Print E-mail
Sunday, 31 March 2013 12:36

The sooner a person smokes a cigarette upon waking in the morning, the more likely he or she is to acquire lung or oral cancer, according to Penn State researchers.

"We found that smokers who consume cigarettes immediately after waking have higher levels of NNAL -- a metabolite of the tobacco-specific carcinogen NNK -- in their blood than smokers who refrain from smoking a half hour or more after waking, regardless of how many cigarettes they smoke per day," said Steven Branstetter, assistant professor of biobehavioral health.

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Details of gene pathways suggest fine-tuning drugs for child brain tumors PDF Print E-mail
Tuesday, 26 March 2013 22:06

Genomic, molecular findings by CHOP researchers will help inform personalized medicine

Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments. A new study offers glimpses into how scientists will be using the ongoing flood of gene-sequencing data to customize treatments based on very specific mutations in a child's tumor.

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Tumors deliberately create conditions that inhibit body's best immune response PDF Print E-mail
Saturday, 02 March 2013 21:45

New research in the Journal of Clinical Investigation reveals that tumours in melanoma patients deliberately create conditions that knock out the body's 'premier' immune defence and instead attract a weaker immune response unable to kill off the tumour's cancerous cells.

The study also highlights a potential antibody biomarker that could help predict prognosis and identify which patients are most likely to respond to specific treatments.

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CU study suggests link between tumor suppressors and starvation survival PDF Print E-mail
Friday, 10 May 2013 22:51

A particular tumor suppressor gene that fights cancer cells does more than clamp down on unabated cell division -- the hallmark of the disease -- it also can help make cells more fit by allowing them to fend off stress, says a University of Colorado Boulder study.

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How does pregnancy reduce breast cancer risk? PDF Print E-mail
Sunday, 28 April 2013 22:16

Being pregnant while young is known to protect a women against breast cancer. But why? Research in BioMed Central's open access journal Breast Cancer Research finds that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.

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Physicists, biologists unite to expose how cancer spreads PDF Print E-mail
Sunday, 28 April 2013 21:53

Cancer cells that can break out of a tumor and invade other organs are more aggressive and nimble than nonmalignant cells, according to a new multi-institutional nationwide study. These cells exert greater force on their environment and can more easily maneuver small spaces.

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Commonly used drug can limit radiation damage to lungs and heart for cancer patients PDF Print E-mail
Sunday, 21 April 2013 06:08

Geneva, Switzerland: Unavoidable damage caused to the heart and lungs by radiotherapy treatment of tumours in the chest region can be limited by the administration of an ACE inhibitor, a drug commonly used in the treatment of cardiovascular disease, a group of Dutch researchers have found. [1]

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Same protein that fires up cancer-promoting Erk also blocks its activation PDF Print E-mail
Sunday, 21 April 2013 05:51

Union with Shc keeps potential troublemaker away from bad company and out of the nucleus

HOUSTON – A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology.

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Cancer checkpoint PDF Print E-mail
Saturday, 06 April 2013 17:05

Mitochondrial metabolic regulator SIRT4 guards against DNA damage

Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them.

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Blood tests can provide fuller picture of mutations in cancer than traditional biopsies do PDF Print E-mail
Saturday, 06 April 2013 16:54

WASHINGTON-- A new blood test revealed more of the gene mutations that sustain certain digestive-tract tumors than did a DNA analysis of a traditional tumor biopsy, Dana-Farber Cancer Institute investigators will report at a special symposium of the American Association for Cancer Research annual meeting in Washington, April 6-10.

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Estrogen plus progestin use linked with increased breast cancer incidence and mortality PDF Print E-mail
Sunday, 31 March 2013 12:28

Estrogen plus progestin use is linked with increased breast cancer incidence. In addition, prognosis is similar for both users and nonusers of combined hormone therapy, suggesting that mortality from breast cancer may be higher for hormone therapy users as well, according to a study published March 29 in the Journal of the National Cancer Institute.

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University of Montreal researchers discover how drug prevents aging and cancer progression PDF Print E-mail
Tuesday, 26 March 2013 21:47

University of Montreal researchers have discovered a novel molecular mechanism that can potentially slows the aging process and may prevent the progression of some cancers. In the March 23 online edition of the prestigious journal Aging Cell, scientists from the University of Montreal explain how they found that the antidiabetic drug metformin reduces the production of inflammatory cytokines that normally activate the immune system, but if overproduced can lead to pathological inflammation, a condition that both damages tissues in aging and favors tumor growth.

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New chemical probe provides tool to investigate role of malignant brain tumor domains PDF Print E-mail
Saturday, 02 March 2013 21:31

CHAPEL HILL, N.C. – In an article published as the cover story of the March 2013 issue of Nature Chemical Biology, Lindsey James, PhD, research assistant professor in the lab of Stephen Frye, Fred Eshelman Distinguished Professor in the UNC School of Pharmacy and member of the UNC Lineberger Comprehensive Cancer Center, announced the discovery of a chemical probe that can be used to investigate the L3MBTL3 methyl-lysine reader domain. The probe, named UNC1215, will provide researchers with a powerful tool to investigate the function of malignant brain tumor (MBT) domain proteins in biology and disease.

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