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Biomarkers & Drug Targets
Gene Defect Predisposes People to Leukemia PDF Print E-mail
Thursday, 08 September 2011 00:02
A new genetic defect that predisposes people to acute myeloid leukemia and myelodysplasia has been discovered. The mutations were found in the GATA2 gene.
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New Chemical Reagent Turns Mouse Brain Transparent PDF Print E-mail
Saturday, 03 September 2011 00:16
Researchers at RIKEN, Japan's flagship research organization, have developed a ground-breaking new aqueous reagent which literally turns biological tissue transparent.
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Positive Results for Phase III Pediatric Trial with Eisai’s Zonegran Epilepsy Drug PDF Print E-mail
Saturday, 03 September 2011 00:07

Eisai reported positive data from a Phase III trial evaluating the antiepilepsy drug Zonegran® (zonisamide) as adjunctive therapy in pediatric patients with partial-onset seizures. The placebo-controlled CATZ study included 207 patients aged 6–17 years with partial-onset seizures, who were already taking one or two antiepileptic drugs.

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Detailed Map of Gene Activity in Mouse Brain Completed PDF Print E-mail
Thursday, 01 September 2011 00:07
A new atlas of gene expression in the mouse brain provides insight into how genes work in the outer part of the brain called the cerebral cortex. In humans, the cerebral cortex is the largest part of the brain, and the region responsible for memory, sensory perception and language.
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Could a Tumor Suppressor Also Fight Obesity? Research Reveals Hormone Receptor GCC's Role in Appetite PDF Print E-mail
Tuesday, 30 August 2011 00:56
The hormone receptor guanylyl cyclase C (GCC) has been established as a suppressor of colorectal cancer tumors, but new evidence from Thomas Jefferson University suggests it may also help fight one of the country's biggest pandemics: obesity.
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Scientists Define Cellular Pathway Essential to Removing Damaged Mitochondria PDF Print E-mail
Saturday, 27 August 2011 00:13
In a joint research effort with researchers at St. Jude Children's Research Hospital, and with help from scientists at The University of Pennsylvania, The University of Minnesota, and the National Institutes of Health, investigators from the Florida campus of The Scripps Research Institute have defined a specific protein complex that allows cells to rid themselves of damaged mitochondria, which are the energy producing machines of the cell.
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Confirmation That Vitamin D Acts as a Protective Agent Against the Advance of Colon Cancer PDF Print E-mail
Saturday, 27 August 2011 00:09
A study conducted by VHIO researchers confirms that a lack of vitamin D increases the aggressiveness of colon cancer.
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Toxicity of Aromatase Inhibitors May Explain Lack of Overall Survival Improvement PDF Print E-mail
Thursday, 25 August 2011 00:57

The toxicities associated with aromatase inhibitors (AIs) may explain the lack of overall survival improvement compared with tamoxifen, according to a study published August 22 in the Journal of The National Cancer Institute.

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Saffron Shows Promise in Preventing Liver Cancer, Study Suggests PDF Print E-mail
Thursday, 25 August 2011 00:02
New research suggests that saffron provides a significant chemopreventive effect against liver cancer in animal models. When saffron was administered to rats with diethylnitrosamine (DEN)-induced liver cancer an inhibition of cell proliferation and stimulation of apoptosis was observed.
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Mutant Gene Identified That Causes Abnormal Chromosome Count, Leading to Cancer PDF Print E-mail
Tuesday, 23 August 2011 00:39
Cells with too few or too many chromosomes have long been known to be a hallmark of cancer -- but the cause of this abnormal number of chromosomes has been little understood.
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New Understanding of Role of Telomeres in Tumor Growth PDF Print E-mail
Tuesday, 06 September 2011 00:13
The first report of the presence of alternative lengthening of telomeres (ALT) in cancers arising from the bladder, cervix, endometrium, esophagus, gallbladder, liver, and lung was published September 1 in The American Journal of Pathology.
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Third Genetic Link to Osteoarthritis Discovered PDF Print E-mail
Saturday, 03 September 2011 00:14
Researchers have just revealed a new gene associated with osteoarthritis. This is only the third gene to be identified for this painful and debilitating disease that affects more than 40 per cent of people aged more than 70 years.
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Genetic Link to Mesothelioma Discovered PDF Print E-mail
Thursday, 01 September 2011 00:52
Scientists have found that individuals who carry a mutation in a gene called BAP1 are susceptible to developing two forms of cancer -- mesothelioma, and melanoma of the eye. Additionally, when these individuals are exposed to asbestos or similar mineral fibers, their risk of developing mesothelioma, an aggressive cancer of the lining of the chest and abdomen, may be markedly increased.
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New Prostate Cancer Screening Test Shows Promise for Diagnosis PDF Print E-mail
Tuesday, 30 August 2011 00:58
A new prostate screening test developed by AnalizaDx, Inc., a Cleveland-based biotech company, and studied by researchers at the Seidman Cancer Center at University Hospitals (UH) Case Medical Center along with colleagues at the Cleveland Clinic, the Veterans Administration Boston Healthcare and the National Cancer Institute, may prove to be a promising new tool in the diagnosis of prostate cancer.
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Cell Receptor Could Allow Measles Virus to Target Tumors PDF Print E-mail
Tuesday, 30 August 2011 00:53
Canadian researchers have discovered that a tumor cell marker is a receptor for measles virus, suggesting the possible use of measles virus to help fight cancer.

Their findings appear in the Open Access journal PLoS Pathogens.

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Brain Tumors Found to Have a Two-Tier System PDF Print E-mail
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Saturday, 27 August 2011 00:12
Ependymomas are the second most frequent type of malignant brain tumor in children. Ependymoma develops from precursor cells of the tissue that lines the hollow cavities of the brain.
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Blood Vessels Participate in the Eradication of Tumors PDF Print E-mail
Friday, 26 August 2011 00:17
Breast cancer: for the first time, very specific blood vessels have been discovered in tumors. These vessels facilitate the access of certain white blood cells, known as "killer lymphocytes," into tumor tissues and thus lead to the efficient destruction of tumors.
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Sweet Insight: Discovery Could Speed Drug Development PDF Print E-mail
Thursday, 25 August 2011 00:07

The surface of cells and many biologically active molecules are studded with sugar structures that are not used to store energy, but rather are involved in communication, immunity and inflammation.

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Computational Method Predicts New Uses for Existing Medicines; Match-Making Program Uses Gene Expression Patterns PDF Print E-mail
Tuesday, 23 August 2011 00:42
For the first time ever, scientists are using computers and genomic information to predict new uses for existing medicines.
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New Research Reveals Brain's Protection Mechanism During Stroke PDF Print E-mail
Tuesday, 23 August 2011 00:37
Neuroscientists have identified a natural protection mechanism in some of the brain's nerve cells during the onset of stroke. The findings, published Aug. 17 in the Journal of Neuroscience, could be used to develop treatments to protect other nerve cell types responsible for speech and movement.
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