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Biomarkers & Drug Targets
Breast Cancer: Stress Receptor Found to Stimulate Growth and Migration of Cancer Cells PDF Print E-mail
Saturday, 24 September 2011 00:13
It's a common belief that there's a link between chronic stress and an increased risk of cancer. In new research published online by the International Journal of Cancer, scientists at The University of Western Ontario have taken a step toward confirming that belief.
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Soy Peptide Plus Chemo Drug Block Colon Cancer's Spread to Liver, Study Finds PDF Print E-mail
Thursday, 22 September 2011 00:19
A University of Illinois study reports a promising new weapon in treating metastatic colon cancer, particularly in patients who have developed resistance to chemotherapy.
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Shark Compound Proves Potential as Drug to Treat Human Viruses, Says Researcher PDF Print E-mail
Thursday, 22 September 2011 00:16
A compound initially isolated from sharks shows potential as a unique broad-spectrum human antiviral agent, according to a study led by a Georgetown University Medical Center investigator and reported in the Proceedings of the National Academy of Sciences Early Edition online Sept. 19.
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Potential Molecular Target to Prevent Growth of Cancer Cells Identified PDF Print E-mail
Tuesday, 20 September 2011 00:56
Researchers have shown for the first time that the protein fortilin promotes growth of cancer cells by binding to and rendering inert protein p53, a known tumor suppressor. This finding by researchers at the University of Texas Medical Branch may lead to treatments for a range of cancers and atherosclerosis, which p53 also helps prevent, and appears in the current print issue of the Journal of Biological Chemistry.
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Blood Proteins Associated With Early Development of Lung Cancer: Discovery Brings Promise of Blood Test to Detect the Disease a Step Closer PDF Print E-mail
Saturday, 17 September 2011 00:59
A research team led by Fred Hutchinson Cancer Research Center has discovered proteins in the blood that are associated with early lung cancer development in mice and humans. The advance brings the reality of a blood test for the early detection and diagnosis of lung cancer a step closer.
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Evolution of a Gene Provides a Possible Explanation for the Development of Metastases and Mental Retardation PDF Print E-mail
Saturday, 17 September 2011 00:08
In the course of examining the Drosophila tumor suppressor gene (Dlg), scientists at the Helmholtz Zentrum München have succeeded in decoding a new mechanism that regulates cell polarity in epithelial tissues or in neurons in the brain.
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Breast Cancer Patients With BRCA Gene Diagnosed Almost Eight Years Earlier Than Generation Before PDF Print E-mail
Thursday, 15 September 2011 00:41
Women with a deleterious gene mutation are diagnosed with breast cancer almost eight years earlier than relatives of the previous generation who also had the disease and/or ovarian cancer, according to new research from The University of Texas MD Anderson Cancer Center.
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Researcher Sees Spring-Like Protein as Key to Muscle Behavior PDF Print E-mail
Tuesday, 13 September 2011 00:47
An idea with its origins in ballistic prey catching -- the way toads and chameleons snatch food with their tongues -- may change fundamental views of muscle movement while powering a new approach to prosthetics.
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Novel Approach Scores First Success Against Elusive Cancer Gene PDF Print E-mail
Tuesday, 13 September 2011 00:33
Dana-Farber Cancer Institute scientists have successfully disrupted the function of a cancer gene involved in the formation of most human tumors by tampering with the gene's "on" switch and growth signals, rather than targeting the gene itself. The results, achieved in multiple myeloma cells, offer a promising strategy for treating not only myeloma but also many other cancer types driven by the gene MYC, the study authors say.
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Loss of Key Estrogen Regulator May Lead to Metabolic Syndrome and Atherosclerosis PDF Print E-mail
Saturday, 10 September 2011 00:32
UCLA researchers demonstrated that loss of a key protein that regulates estrogen and immune activity in the body could lead to aspects of metabolic syndrome, a combination of conditions that can cause Type 2 diabetes, atherosclerosis and cancer.
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Key Molecule That Blocks Abnormal Blood Vessel Growth in Tumors Identified PDF Print E-mail
Saturday, 24 September 2011 00:11
A new and better understanding of blood vessel growth and vascular development (angiogenesis) in cancer has been made possible by research carried out by a team of scientists from Moffitt Cancer Center, the University of Florida, Harvard University, Yale University and the Children's Hospital of Los Angeles.
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Key Regulatory Genes Often Amplified in Aggressive Childhood Tumor of the Brainstem PDF Print E-mail
Thursday, 22 September 2011 00:18
The largest study ever of a rare childhood brain tumor found more than half the tumors carried extra copies of specific genes linked to cancer growth, according to research led by St. Jude Children's Research Hospital investigators.
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Targeting Cholesterol to Fight Deadly Brain Cancers PDF Print E-mail
Tuesday, 20 September 2011 00:58
Blocking the uptake of large amounts of cholesterol into brain cancer cells could provide a new strategy to battle glioblastoma, one of the most deadly malignancies, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.
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Unconventional Hunt for New Cancer Targets Leads to a Powerful Drug Candidate for Leukemia PDF Print E-mail
Tuesday, 20 September 2011 00:06
Scientists at Cold Spring Harbor Laboratory (CSHL) and five other institutions have used an unconventional approach to cancer drug discovery to identify a new potential treatment for acute myeloid leukemia (AML). As reported in Nature online on August 3, the scientists have pinpointed a protein called Brd4 as a novel drug target for AML, an aggressive blood cancer that is currently incurable in 70% of patients.
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Newly Discovered Protein Discovered May Suppress Breast Cancer Growth PDF Print E-mail
Saturday, 17 September 2011 00:20
Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, has found that a protein discovered by his laboratory can inhibit the growth of breast cancer cells.
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Protein BVES Identified as a Suppressor of Colorectal Cancer Progression PDF Print E-mail
Thursday, 15 September 2011 00:44
Once a cancer gains the ability to invade local tissues and spread to a distant site it becomes much harder to treat. A team of researchers, led by Min Chang and Christopher Williams, at Vanderbilt University School of Medicine,
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X-Ray Protein Probe Leads to Potential Anticancer Tactic PDF Print E-mail
Thursday, 15 September 2011 00:38
Researchers at Emory University School of Medicine have identified a new type of potential anticancer drug. The compound, named FOBISIN, targets 14-3-3 proteins, important for the runaway growth of cancer cells.
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Cancer: Antibodies Can Directly Target Oncoproteins Inside Cancer Cells to Suppress Aggressive Cancer Growth PDF Print E-mail
Tuesday, 13 September 2011 00:44
Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have made a landmark discovery in the battle against the rapid spread of aggressive cancers associated with PRL-3 oncoprotein[1]. Contrary to the current accepted theory that antibodies can only bind to cancer proteins found on the cancer cell surface, the IMCB team led by Dr Zeng Qi is the first to discover that antibodies can in fact directly target intracellular oncoproteins like PRL-3 that reside within the cancer cells to suppress cancer growth successfully.
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A Step Toward a Saliva Test for Cancer PDF Print E-mail
Saturday, 10 September 2011 00:33
A new saliva test can measure the amount of potential carcinogens stuck to a person's DNA -- interfering with the action of genes involved in health and disease -- and could lead to a commercial test to help determine risks for cancer and other diseases, scientists reported in Denver during the 242nd National Meeting & Exposition of the American Chemical Society (ACS).
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New Strategy for Overcoming Resistance to Targeted Cancer Drug PDF Print E-mail
Saturday, 10 September 2011 00:30
Scientists at Dana-Farber Cancer Institute and colleagues overseas have discovered a pair of backup circuits in cancer cells that enable the cells to dodge the effect of a widely used cancer drug. Jamming those circuits with targeted therapies may heighten or restore the drug's potency, according to a study published in the Sept. 7 issue of Science Translational Medicine.
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