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Biomarkers & Drug Targets
Biomarker Detects Graft-Versus-Host-Disease in Cancer Patients After Bone Marrow Transplant PDF Print E-mail
Monday, 24 October 2011 00:20

A University of Michigan Health System-led team of researchers has found a biomarker they believe can help rapidly identify one of the most serious complications in patients with leukemia, lymphoma and other blood disorders who have received a transplant of new, blood-forming cells.

First Genome-Wide Association Study for Dengue Identifies Candidate Susceptibility Genes PDF Print E-mail
Thursday, 20 October 2011 00:19
Researchers in South East Asia have identified two genetic variants associated with increased susceptibility to severe dengue. The study, funded by the Wellcome Trust and the Agency for Science, Technology, and Research, Singapore, offers clues to how the body responds to dengue infection.
Gut Bacteria May Affect Whether a Statin Drug Lowers Cholesterol PDF Print E-mail
Tuesday, 18 October 2011 00:50
Statins can be effective at lowering cholesterol, but they have a perplexing tendency to work for some people and not others. Gut bacteria may be the reason.
Researchers Block Morphine's Itchy Side Effect PDF Print E-mail
Tuesday, 18 October 2011 00:32
Itching is one of the most prevalent side effects of powerful, pain-killing drugs like morphine, oxycodone and other opioids. The opiate-associated itch is so common that even women who get epidurals for labor pain often complain of itching. For many years, scientists have scratched their own heads about why drugs that so effectively suppress pain also induce itch.
Study Shows Increased Prostate Cancer Risk from Vitamin E Supplements PDF Print E-mail
Saturday, 15 October 2011 00:19

Men who took 400 international units (I.U.) of vitamin E daily had more prostate cancers compared to men who took a placebo, according to an updated review of data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

Gene Signature Predicts Oral Cancer Recurrence PDF Print E-mail
Thursday, 13 October 2011 00:15

Oral Squamous Cell Carcinoma (OSCC) is responsible for nearly a quarter of all head and neck cancers. It is one of the leading causes of cancer death -- largely due to the failure of current histological procedures in predicting the recurrence of the disease.

Scientists Discover Three New Gene Faults Which Could Increase Melanoma Risk by 30 Percent PDF Print E-mail
Thursday, 13 October 2011 00:11
An international team of researchers has discovered the first DNA faults linked to melanoma -- the deadliest skin cancer -- that are not related to hair, skin or eye colour.
Imaging Agents Offer New View of Inflammation, Cancer PDF Print E-mail
Tuesday, 11 October 2011 00:55
A series of novel imaging agents could make it possible to "see" tumors in their earliest stages, before they turn deadly.

The compounds, derived from inhibitors of the enzyme cyclooxygenase-2 (COX-2) and detectable by positron emission tomography (PET) imaging, may have broad applications for cancer detection, diagnosis and treatment.

Dioxin-Like Chemical Messenger Makes Brain Tumors More Aggressive PDF Print E-mail
Saturday, 08 October 2011 01:30
A research alliance of Heidelberg University Hospital and the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), jointly with colleagues of the Helmholtz Center for Environmental Research in Leipzig, has discovered a new metabolic pathway which makes malignant brain tumors (gliomas) more aggressive and weakens patients' immune systems.
Popular Colorectal Cancer Drug May Cause Permanent Nerve Damage, Study Suggests PDF Print E-mail
Saturday, 01 October 2011 00:57

Oxaliplatin, a platinum-based anticancer drug that's made enormous headway in recent years against colorectal cancer, appears to cause nerve damage that may be permanent and worsens even months after treatment ends.

Protein Family Key to Aging, Cancer PDF Print E-mail
Thursday, 20 October 2011 00:56

The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health (NIH).

Possible Link Between Bacterium and Colon Cancer Discovered PDF Print E-mail
Thursday, 20 October 2011 00:00

Scientists at Dana-Farber Cancer Institute and the Broad Institute have found strikingly high levels of a bacterium in colorectal cancers, a sign that it might contribute to the disease and potentially be a key to diagnosing, preventing, and treating it.

Why Many Cells Are Better Than One: Limited Decision-Making Ability of Individual Cells Is Bolstered in Masses PDF Print E-mail
Tuesday, 18 October 2011 00:48
Researchers from Johns Hopkins have quantified the number of possible decisions that an individual cell can make after receiving a cue from its environment, and surprisingly, it's only two.
Ovarian Cancer Patients Survive Longer With BRCA2 Mutated in Tumors, Study Finds PDF Print E-mail
Saturday, 15 October 2011 00:21
Women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations, researchers at The University of Texas MD Anderson Cancer Center and the Institute for Systems Biology report in the Oct. 12 issue of the Journal of the American Medical Association.
Ginger Root Supplement Reduced Colon Inflammation Markers PDF Print E-mail
Saturday, 15 October 2011 00:16

Ginger supplements reduced markers of colon inflammation in a select group of patients, suggesting that this supplement may have potential as a colon cancer prevention agent, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research.

Small Molecules Can Starve Cancer Cells PDF Print E-mail
Thursday, 13 October 2011 00:13
All cells in our body have a system that can handle cellular waste and release building blocks for recycling. The underlying mechanism is called autophagy and literally means "self-eating."
Marijuana Component Could Ease Pain from Chemotherapy Drugs, Study Suggests PDF Print E-mail
Tuesday, 11 October 2011 00:57
A chemical component of the marijuana plant could prevent the onset of pain associated with drugs used in chemo therapy, particularly in breast cancer patients, according to researchers at Temple University's School of Pharmacy.

The researchers published their findings in the journal Anesthesia and Analgesia.

Unprecedented Insight Into Fighting Viral Infections PDF Print E-mail
Tuesday, 11 October 2011 00:53
Researchers at Rutgers and UMDNJ-Robert Wood Johnson Medical School have determined the structure of a protein that is the first line of defense in fighting viral infections including influenza, hepatitis C, West Nile, rabies, and measles.
Worm 'Cell Death' Discovery Could Lead to New Drugs for Deadly Parasite PDF Print E-mail
Saturday, 08 October 2011 01:28

Researchers from the Walter and Eliza Hall Institute have for the first time identified a 'programmed cell death' pathway in parasitic worms that could one day lead to new treatments for one of the world's most serious and prevalent diseases.

Gene May Be Good Target for Tough-To-Kill Prostate Cancer Cells PDF Print E-mail
Saturday, 01 October 2011 00:45
Purdue University scientists believe they have found an effective target for killing late-stage, metastatic prostate cancer cells.

Xiaoqi Liu, an assistant professor of biochemistry and member of Purdue's Center for Cancer Research, and graduate student Shawn Liu are focusing on the function of a gene called Polo-like kinase (Plk1), a critical regulator of the cell cycle.

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