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Trinity researchers report major eye disease breakthrough PDF Print E-mail
Sunday, 08 April 2012 21:23

Controlling an inflammatory component IL-18 in age-related macular degeneration could prevent the development of the disease

Scientists at Trinity College Dublin have discovered that a part of the immune system called the inflammasome is involved in regulating the development of one of the most common forms of blindness, called Age-Related Macular Degeneration (AMD). They have discovered that controlling an inflammatory component IL-18, in cases of Age-Related Macular Degeneration (AMD) could prevent the development of the disease.

New discovery may lead to effective prevention and treatment of graft-versus-host dsease PDF Print E-mail
Sunday, 01 April 2012 04:54

New research in mice published in the Journal of Leukocyte Biology suggests that the platelet activating factor receptor plays a role in graft-versus-host disease, a major complication of bone marrow transplants

Antidepressant proves effective in alleviating osteoarthritis pain PDF Print E-mail
Thursday, 22 March 2012 06:46

Antidepressants can play a key role in alleviating painful conditions like osteoarthritis and may result in fewer side effects than traditionally prescribed drug regimes, such as anti-inflammatories and opioids, according to a perspective paper published online ahead of print publication by the International Journal of Clinical Practice.

NIH study links childhood cancer to developmental delays in milestones PDF Print E-mail
Sunday, 11 March 2012 01:50

Language, motor deficits, seen within months of starting treatment

Infants and toddlers who have been treated for cancer tend to reach certain developmental milestones later than do their healthy peers, say researchers at the National Institutes of Health and in Italy.

Surgery less than 24 hours after traumatic cervical spinal cord injury leads to improved outcomes PDF Print E-mail
Wednesday, 07 March 2012 05:45

(PHILADELPHIA) – Researchers at the Rothman Institute at Jefferson have shown that patients who receive surgery less than 24 hours after a traumatic cervical spine injury suffer less neural tissue destruction and improved clinical outcomes. The results of their study, the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS) are available in PLoS One.

Faulty fat sensor implicated in obesity and liver disease PDF Print E-mail
Sunday, 19 February 2012 23:59

Defects in a protein that functions as a dietary fat sensor may be a cause of obesity and liver disease, according to a study published in the journal Nature, led by researchers at Imperial College London. The findings highlight a promising target for new drugs to treat obesity and metabolic disorders.

The protein GPR120 is found on the surface of cells in the gut, liver and fat tissue and allows cells to detect and respond to unsaturated fatty acids from the diet, especially the omega-3 fatty acids which are believed to have a beneficial impact on health. Scientists found that mice deficient in GPR120 were more prone to developing obesity and liver disease when fed a high-fat diet. They also found that people with a certain mutation in the gene encoding GPR120, which stops the protein from responding to omega-3 fatty acids, were significantly more likely to be obese.

Diabetes may start in the intestines, research suggests PDF Print E-mail
Thursday, 16 February 2012 00:01

Scientists at Washington University School of Medicine in St. Louis have made a surprising discovery about the origin of diabetes. Their research suggests that problems controlling blood sugar — the hallmark of diabetes — may begin in the intestines.

The new study, in mice, may upend long-held theories about the causes of the disease. Because insulin is produced in the pancreas and sugar is stored in the liver, many scientists have looked to those organs for the underlying causes of diabetes.

Researchers discover molecular secrets of ancient Chinese herbal remedy PDF Print E-mail
Sunday, 12 February 2012 17:17

2,000-year-old herb regulates autoimmunity and inflammation

BOSTON, Mass. (February 12, 2012)—For roughly two thousand years, Chinese herbalists have treated Malaria using a root extract, commonly known as Chang Shan, from a type of hydrangea that grows in Tibet and Nepal. More recent studies suggest that halofuginone, a compound derived from this extract's bioactive ingredient, could be used to treat many autoimmune disorders as well. Now, researchers from the Harvard School of Dental Medicine have discovered the molecular secrets behind this herbal extract's power.

Risks of pregnancy via egg donation similar for women over age 50 as for younger women PDF Print E-mail
Tuesday, 31 January 2012 22:47

(NEW YORK, NY, January 31, 2012) – Although women over age 50 who become pregnant via egg donation are at an elevated risk for developing obstetrical complications, their complication rates are similar to those of younger recipients, according to a study by Columbia University Medical Center researchers to be published in the February 2012 issue of the American Journal of Perinatology. This is contrary to epidemiological data suggesting that these women are at greater risk of certain complications of pregnancy, including hypertension, gestational diabetes, premature birth, and placenta abnormalities.

Towards more effective treatment for multiple myeloma PDF Print E-mail
Monday, 09 January 2012 23:23

SUNY downstate researchers find protein inhibitor has potent anti-tumor effects

A new study from SUNY Downstate Medical Center in Brooklyn, New York, shows that MAL3-101, a recently developed inhibitor of the heat shock protein 70 (Hsp70), appears to have potent anti-tumor effects on multiple myeloma, a bone marrow cancer. Despite aggressive modes of treatments, myeloma ultimately remains incurable. The disease has a high incidence in the communities served by SUNY Downstate.

Women cannot rewind the 'biological clock' PDF Print E-mail
Sunday, 08 April 2012 20:29

Many women do not fully appreciate the consequences of delaying motherhood, and expect that assisted reproductive technologies can reverse their aged ovarian function, Yale researchers reported in a study published in a recent issue of Fertility and Sterility.

Study examines treatment of heart failure with bone marrow cells PDF Print E-mail
Sunday, 25 March 2012 06:38

Use of a patient's bone marrow cells for treating chronic ischemic heart failure did not result in improvement on most measures of heart function, according to a study appearing in JAMA. The study is being published early online to coincide with its presentation at the American College of Cardiology's annual scientific sessions.

Obesity raises death risk tied to sleeping pills PDF Print E-mail
Saturday, 17 March 2012 19:23

New findings delivered at American Heart Association meeting also show heightened risk in men and young adults

SAN DIEGO -- Obesity appears to significantly increase the risk of death tied to sleeping pills, nearly doubling the rate of mortality even among those prescribed 18 or fewer pills in a year, researchers reported Friday.

LA BioMed investigator, Dr. Rowan Chlebowski, co-authors study on menopausal hormone therapy PDF Print E-mail
Sunday, 11 March 2012 01:45

Study indicates use of estrogen-only form of menopausal hormone therapy continues to protect women from breast cancer

LOS ANGELES (March 9, 2012) – Rowan T. Chlebowski, M.D., Ph.D., an LA BioMed investigator whose research activities have focused on breast cancer therapy and prevention, and chronic diseases impacting women's health, is co-author of a study that indicates that women who use the estrogen-only form of menopausal hormone therapy appear less likely to develop breast cancer in the longer term, according to new research which was recently published The Lancet Oncology.

How to rescue the immune system PDF Print E-mail
Sunday, 26 February 2012 23:26

Study in Nature Medicine could lead to novel therapy for cancer

MAYWOOD, Ill. – In a study published in Nature Medicine, Loyola researchers report on a promising new technique that potentially could turn immune system killer T cells into more effective weapons against infections and possibly cancer.

New molecule discovered in fight against allergy PDF Print E-mail
Thursday, 16 February 2012 00:22

Scientists at The University of Nottingham have discovered a new molecule that could offer the hope of new treatments for people allergic to the house dust mite.

The team of immunologists led by Dr Amir Ghaem-Maghami and Professor Farouk Shakib in the University’s School of Molecular Medical Sciences have identified the molecule DC-SIGN which appears to play a role in damping down the body’s allergic response to the house dust mite .

UTHealth research: Both maternal and paternal age linked to autism PDF Print E-mail
Sunday, 12 February 2012 17:41

HOUSTON – (Feb. 9, 2012) – Older maternal and paternal age are jointly associated with having a child with autism, according to a recently published study led by researchers at The University of Texas Health Science Center at Houston (UTHealth).

44 percent of postmenopausal women with distal radius fracture have low levels of vitamin D PDF Print E-mail
Tuesday, 07 February 2012 21:46

Preventative efforts may reduce the number of hip fractures

SAN FRANCISCO – Wrist fractures, also called distal radius fractures (DRF), are among the most common osteoporosis-related fractures occurring on average 15 years earlier than hip fractures. As vitamin D deficiency has recently been linked with muscle weakness, increased fall risks, and bone fractures, investigators sought to determine the prevalence of vitamin D deficiency among post menopausal women with DRF. The study, "Hypovitaminosis D in Postmenopausal Women with a Distal Radius Fracture," was presented today at the 2012 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS).

Mass. General researchers find novel way to prevent drug-induced liver injury PDF Print E-mail
Sunday, 15 January 2012 11:51

Blocking cell-to-cell communication may prevent liver damage and improve drug safety

Massachusetts General Hospital (MGH) investigators have developed a novel strategy to protect the liver from drug-induced injury and improve associated drug safety. In their report receiving advance online publication in the journal Nature Biotechnology, the team reports that inhibition of a type of cell-to-cell communication can protect against the damage caused by liver-toxic drugs such as acetaminophen.

Insulin therapy may help repair atherosclerotic lesions in diabetic patients PDF Print E-mail
Monday, 09 January 2012 23:17

New research published in the American Journal of Pathology

Philadelphia, PA, January 9, 2012 – New research reveals that insulin applied in therapeutic doses selectively stimulates the formation of new elastic fibers in cultures of human aortic smooth muscle cells. These results advance the understanding of the molecular and cellular mechanisms of diabetic vascular disease. The study is published in the February issue of the American Journal of Pathology.

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