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CNIO researchers discover a new regulator of drug detoxification PDF Print E-mail
Saturday, 12 October 2013 21:14

The CNIO group led by researcher Erwin Wagner discovered that the Fra-1 protein is causally involved in liver fibrosis and protects the liver from drug-induced liver damage

Drug abuse and alcohol are some of the most frequent causes of liver damage, particularly in developed countries. Such kind of liver damage can cause irreversible liver failure and even cancer. Researchers from the Spanish National Cancer Research Centre (CNIO) have discovered an important new protective role of the Fra-1 protein, which neutralizes the damage caused by agents, such as the analgesic drug acetaminophen (Paracetamol). This is the first study to reveal a function of Fra-1 in protecting this important organ. The study is published today in the journalHepatology.

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Study reveals the face of sleep deprivation PDF Print E-mail
Saturday, 31 August 2013 06:23

Sleep deprivation has noticeable effects on facial appearance that may have social consequences

DARIEN, IL – A new study finds that sleep deprivation affects facial features such as the eyes, mouth and skin, and these features function as cues of sleep loss to other people.

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Gut taste mechanisms are abnormal in diabetes sufferers PDF Print E-mail
Saturday, 24 August 2013 15:52

Researchers at the University of Adelaide have discovered that the way the gut "tastes" sweet food may be defective in sufferers of type 2 diabetes, leading to problems with glucose uptake.

This is the first time that abnormal control of so-called "sweet taste receptors" in the human intestine has been described by researchers. The work could have implications for a range of health and nutrition problems experienced by diabetes patients.

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High cholesterol riskier for middle-aged men than women PDF Print E-mail
Saturday, 17 August 2013 21:25

High cholesterol levels are much more risky for middle-aged men than middle-aged women when it comes to having a first heart attack, a new study of more than 40,000 Norwegian men and women has shown.

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How to Stop Bleeding in the ER Caused by Warfarin PDF Print E-mail
Sunday, 04 August 2013 22:14

WASHINGTON — Prothrombin complex concentrates (PCCs) are faster and more effective than fresh frozen plasma at reversing hemorrhage caused by the anti-coagulant warfarin, despite plasma being the most commonly used therapy.  A literature review published last month in Annals of Emergency Medicine suggests that physicians in the United States should join those around the world in following recommendations of multiple specialty organizations to use PCCs as the first line of defense in this common and life-threatening emergency (“Rapid Reversal of Warfarin-Associated Hemorrhage in the Emergency Department by Prothrombin Complex Concentrates”).

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U of T-led study cracks universal RNA code, suggests a new cause for autism PDF Print E-mail
Saturday, 13 July 2013 21:56

The discovery cracks the "RNA control code," which dictates how RNA — a family of molecules that mediates DNA expression — moves genetic information from DNA to create proteins.

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Americans' vitamin D levels are highest in August, lowest in February, study shows PDF Print E-mail
Saturday, 22 June 2013 22:35

Findings by UCI-Mayo Clinic team will help explain nutrient's role in seasonal illnesses

Irvine, Calif. – UC Irvine and Mayo Clinic researchers have found that vitamin D levels in the U.S. population peak in August and bottom out in February. The essential vitamin – necessary for healthy bones – is produced in the skin upon exposure to ultraviolet B rays from the sun.

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Major hurdle cleared to diabetes transplants PDF Print E-mail
Saturday, 15 June 2013 15:18

Researchers atWashington University School of Medicine in St. Louis have identified a way to trigger reproduction in the laboratory of clusters of human cells that make insulin, potentially removing a significant obstacle to transplanting the cells as a treatment for patients with type 1 diabetes. 

Efforts to make this treatment possible have been limited by a dearth of insulin-producing beta cells that can be removed from donors after death, and by the stubborn refusal of human beta cells to proliferate in the laboratory after harvesting. 

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Non-invasive first trimester blood test reliably detects Down's syndrome PDF Print E-mail
Saturday, 08 June 2013 23:01

New research has found that routine screening using a non-invasive test that analyzes fetal DNA in a pregnant woman's blood can accurately detect Down's syndrome and other genetic fetal abnormalities in the first trimester. Published early online in Ultrasound in Obstetrics & Gynecology, the results suggest that the test is superior to currently available screening strategies and could reshape standards in prenatal testing.

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Study Identifies New Approach to Improving Treatment for Ms And Other Conditions PDF Print E-mail
Saturday, 18 May 2013 06:20

Wenbin Deng Working with lab mice models of multiple sclerosis (MS), UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved medications against MS.

The findings of the research study, published online today in the journalEMBO Molecular Medicine could have therapeutic applications for MS as well as cerebral palsy and leukodystrophies, all disorders associated with loss of white matter, which is the brain tissue that carries information between nerve cells in the brain and the spinal cord.

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Joslin identifies immune cells that promote growth of beta cells in type 1 diabetes PDF Print E-mail
Sunday, 29 September 2013 16:56

Provides new insights into type 1 diabetes pathology

BOSTON – (September 27, 2013) – Joslin researchers have identified immune cells that promote growth of beta cells in type 1 diabetes. This study provides further evidence of a changed role for immune cells in type 1 diabetes pathology. The study will be published online today and will appear in the January issue of Diabetes.

 

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Rheumatoid arthritis: biologics in second-line therapy show benefit PDF Print E-mail
Saturday, 31 August 2013 06:14

Positive effects for all drugs / long-term data and robust direct comparisons are lacking

The German Institute for Quality and Efficiency in Health Care (IQWiG) examined 9 biotechnologically produced drugs for the treatment of adults with rheumatoid arthritis in whom prior pharmacological treatment had failed. According to the findings, for each drug the data provide proof, an indication, or at least a hint of a benefit in relation to at least one outcome criterion. This is the conclusion of the final report published by IQWiG on 26 August 2013.

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Drug dosing for older heart patients should differ PDF Print E-mail
Saturday, 17 August 2013 21:29

DURHAM, N.C. – Older heart patients present unique challenges for determining the optimal dosages of medications, so a new study from researchers at Duke Medicine offers some rare clarity about the use of drugs that are used to treat patients with heart attacks.

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Mechanism that allows bacteria to infect plants may inspire cure for eye disease PDF Print E-mail
Sunday, 04 August 2013 22:34

By borrowing a tool from bacteria that infect plants, scientists have developed a new approach to eliminate mutated DNA inside mitochondria—the energy factories within cells. Doctors might someday use the approach to treat a variety of mitochondrial diseases, including the degenerative eye disease Leber hereditary optic neuropathy (LHON). The research, published online today in Nature Medicine, was funded by the National Eye Institute (NEI), a part of the National Institutes of Health (NIH).

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Calcium linked to increased risk of heart disease and death in patients with kidney disease PDF Print E-mail
Saturday, 20 July 2013 21:56

TORONTO, ON, July 19, 2013 — Kidney patients who take calcium supplements to lower their phosphorous levels may be at a 22 per cent higher risk of death than those who take other non-calcium based treatments, according to a new study by Women's College Hospital's Dr. Sophie Jamal.

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New research could pave the way to safer treatments for arthritis PDF Print E-mail
Saturday, 06 July 2013 17:33

The increased risk of heart attack or stroke associated with many arthritis drugs may be avoidable, according to a new international study co-authored by researchers at Imperial College London.

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Le Bonheur research featured in New England Journal of Medicine PDF Print E-mail
Saturday, 22 June 2013 22:12

Inflammation in the kidney is a serious, common issue among adults and children in North America. Finding noninvasive ways to properly diagnose, monitor and treat the inflammation may be getting easier thanks to research by Robert J. Wyatt, MD, a Le Bonheur nephrologist and professor in the Department of Pediatrics at the University of Tennessee Health Science Center (UTHSC). Wyatt is co-author of a Medical Progress report titled, “IgA Nephropathy” in this week’s edition of the New England Journal of Medicine. His co-author is Bruce A. Julian, MD, in the Department of Medicine at the University of Alabama, Birmingham.

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Sugar overload can damage heart according to UTHealth research PDF Print E-mail
Saturday, 15 June 2013 15:08

Heinrich Taegtmeyer, M.D., D.Phil.HOUSTON – (June 14, 2013) – Too much sugar can set people down a pathway to heart failure, according to a study led by researchers at The University of Texas Health Science Center at Houston (UTHealth).

A single small molecule, the glucose metabolite glucose 6-phosphate (G6P), causes stress to the heart that changes the muscle proteins and induces poor pump function leading to heart failure, according to the study, which was published in the May 21 issue of the Journal of the American Heart Association. G6P can accumulate from eating too much starch and/or sugar.

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Recommended the use of more potent antithrombotic drugs in high-risk heart attack patients PDF Print E-mail
Saturday, 08 June 2013 22:33

The CatSalut protocol implies the immediate transfer of a patient who suffers a heart attack to a center with hemodynamic unit

The Cardiovascular Research Laboratory of the IDIBELL led by the cardiologist of the Bellvitge University Hospital José Luis Ferreiro has conducted a study on the effect of antiplatelet drugs given to high risk patients suffering from acute myocardial infaction (heart attack) in the context of the Infarction Code.

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Gray hair and vitiligo reversed at the root PDF Print E-mail
Sunday, 05 May 2013 00:42

New research in The FASEB Journal suggests that loss of skin or hair color can be corrected by a new compound -- a pseudocatalase -- that reverses oxidative stress

Bethesda, MD—Hair dye manufacturers are on notice: The cure for gray hair is coming. That's right, the need to cover up one of the classic signs of aging with chemical pigments will be a thing of the past thanks to a team of European researchers.

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