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Biochemistry & Biophysics
New Therapy Substitutes Missing Protein In Those With Muscular Dystrophy PDF Print E-mail
Wednesday, 27 May 2009 14:44
Researchers at the University of Minnesota Medical School have discovered a new therapy that shows potential to treat people with Duchenne muscular dystrophy, a fatal disease and the most common form of muscular dystrophy in children.
'Disordered' Amino Acids May Really Be There To Provide Wiggle Room For Signaling Protein PDF Print E-mail
Tuesday, 26 May 2009 14:24
Sections of proteins previously thought to be disordered may in fact have an unexpected biological role — providing certain proteins room to move — according to a study published by researchers at Fox Chase Cancer Center in this month's issue of the journal Structure (Cell Press).
Unusually Large Family Of Green Fluorescent Proteins Discovered In Marine Creature PDF Print E-mail
Saturday, 23 May 2009 11:12
Researchers at Scripps Institution of Oceanography at UC San Diego and the Salk Institute for Biological Studies have discovered a family of green fluorescent proteins (GFPs) in a primitive sea animal, along with new clues about the role of the proteins that has nothing to do with their famous glow.
Long-awaited Atomic Structure Of Well-known Enzyme Solved: Discovery Heralds New Approaches To Protein-engineered Biofuels PDF Print E-mail
Wednesday, 20 May 2009 19:40
A Boston University–led research team has identified the structural underpinnings of a widely-known enzyme -- acetoacetate decarboxylase (AADase) -- that was first described correctly more than 43 years ago including how it accelerates its target reaction. Until now it has never been fully explained how the reactions occur in the environment of the cell.
'Junk' DNA Has Important Role, Researchers Find PDF Print E-mail
Wednesday, 20 May 2009 19:21
Scientists have called it "junk DNA." They have long been perplexed by these extensive strands of genetic material that dominate the genome but seem to lack specific functions. Why would nature force the genome to carry so much excess baggage?
Biomass As A Source Of Raw Materials PDF Print E-mail
Monday, 18 May 2009 20:32
For the protection of the environment, and because of the limited amount of fossil fuels available, renewable resources, such as specially cultivated plants, wood scraps, and other plant waste, are becoming the focus of considerable attention.
Using High-precision Laser Tweezers To Juggle Cells PDF Print E-mail
Friday, 15 May 2009 20:00
Researchers at the University of Gothenburg, Sweden, have developed a new method to study single cells while exposing them to controlled environmental changes. The unique method, where a set of laser tweezers move the cell around in a microscopic channel system, allows the researchers to study how single cells react to stress induced by a constantly changing environment.
Cystathionase Regulated By Farnesoid X Receptor PDF Print E-mail
Friday, 15 May 2009 19:44
The expression and activity of Cystathionase is reduced in rodent models of liver injury, leading to hyper-homocysteinemia and impaired generation of hydrogen sulphide, two factors that contribute to endothelial dysfunction and increased intrahepatic resistance.
Protein-protein interaction explains vision loss in genetic diseases PDF Print E-mail
Wednesday, 13 May 2009 17:46
The mystery of genetic disease is only partially solved with the identification of a mutated gene. Often, the pattern of disease – the features or disorders associated with it – vary in type and severity among those who are affected.

In this week's journal Nature Genetics, an international consortium of researchers, including some from Baylor College of Medicine, provide not only an explanation for the variations of vision loss in people with a host of disorders associated with defective cilia within the cells, but also a blueprint for unravelling similar variations in signs among people with other genetic diseases.
Skin color clue to nicotine dependence PDF Print E-mail
Friday, 08 May 2009 21:03

Higher concentrations of melanin -- the color pigment in skin and hair -- may be placing darker pigmented smokers at increased susceptibility to nicotine dependence and tobacco-related carcinogens than lighter skinned smokers, according to scientists.

"We have found that the concentration of melanin is directly related to the number of cigarettes smoked daily, levels of nicotine dependence, and nicotine exposure among African Americans," said Gary King, professor of biobehavioral health, Penn State.

King states that previous research shows that nicotine has a biochemical affinity for melanin. Conceivably, this association could result in an accumulation of the addictive agent in melanin-containing tissues of smokers with greater amounts of skin pigmentation.

Green Tea Extract Shows Promise In Leukemia Trials PDF Print E-mail
Tuesday, 26 May 2009 14:47
Mayo Clinic researchers are reporting positive results in early leukemia clinical trials using the chemical epigallocatechin gallate (EGCG), an active ingredient in green tea. The trial determined that patients with chronic lymphocytic leukemia (CLL) can tolerate the chemical fairly well when high doses are administered in capsule form and that lymphocyte count was reduced in one-third of participants.
Fundamental Mechanism For Cell Organization Discovered PDF Print E-mail
Saturday, 23 May 2009 11:17
Scientists have discovered that cells use a very simple phase transition -- similar to water vapor condensing into dew -- to assemble and localize subcellular structures that are involved in formation of the embryo.
Function Of Key Protein In Cancer Spread Described By LSUHSC Researchers PDF Print E-mail
Saturday, 23 May 2009 11:07
Research led by David Worthylake, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, may help lay the groundwork for the development of a compound to prevent the spread of cancer. The research will be published in the May 29, 2009 issue of the Journal of Biological Chemistry.
Influenza Virus Evades Body's Immune Response Through Newly Discovered Mechanism PDF Print E-mail
Wednesday, 20 May 2009 19:30
Researchers at the University of Southern California (USC) have identified a critical molecular mechanism that allows the influenza virus to evade the body's immune response system.
How an enzyme tells stem cells which way to divide PDF Print E-mail
Monday, 18 May 2009 20:41
University of Oregon biochemists report a mechanism dictating cell division is not a long cascade of events.

Driving Miranda, a protein in fruit flies crucial to switch a stem cell's fate, is not as complex as biologists thought, according to University of Oregon biochemists. They've found that one enzyme aPKC (atypical protein kinase C) stands alone and acts as a traffic policeman that directs which roads daughter cells will take.
Synthetic Catalyst Mimics Nature's 'Hydrogen Economy' PDF Print E-mail
Monday, 18 May 2009 20:24
By creating a model of the active site found in a naturally occurring enzyme, chemists at the University of Illinois have described a catalyst that acts like nature's most pervasive hydrogen processor.
Progress Toward Artificial Tissue? PDF Print E-mail
Friday, 15 May 2009 19:53
For modern implants and the growth of artificial tissue and organs, it is important to generate materials with characteristics that closely emulate nature. However, the tissue in our bodies has a combination of traits that are very hard to recreate in synthetic materials: It is both soft and very tough.
Breakthrough in the treatment of bacterial meningitis PDF Print E-mail
Wednesday, 13 May 2009 17:52
It can take just hours after the symptoms appear for someone to die from bacterial meningitis.

Now, after years of research, experts at The University of Nottingham have finally discovered how the deadly meningococcal bacterium is able to break through the body’s natural defence mechanism and attack the brain.

The discovery could lead to better treatment and vaccines for meningitis and could save the lives of hundreds of children.
Molecular Structure Could Help Explain Albinism, Melanoma PDF Print E-mail
Wednesday, 13 May 2009 17:01
Arthropods and mollusks are Nature's true bluebloods - thanks to hemocyanin, an oxygen-carrying large protein complex, which can even be turned into the enzymatically active chemical phenoloxidase.

Scientists have long known that members of the phenoloxidase family are involved in skin and hair coloring. When they are mutated, they can cause albinism - the loss of coloring in skin and hair. Produced over abundantly, they are associated with the deadly skin cancer melanoma.
White Tea: Solution To Obesity Epidemic? PDF Print E-mail
Friday, 08 May 2009 20:48
Possible anti-obesity effects of white tea have been demonstrated in a series of experiments on human fat cells (adipocytes). Researchers have now shown that an extract of the herbal brew effectively inhibits the generation of new adipocytes and stimulates fat mobilization from mature fat cells.
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