PROVIDENCE, R.I. [Brown University] — Tiny, transient loops of genetic material, detected and studied by the hundreds for the first time at Brown University, are providing new insights into how the body transcribes DNA and splices (or missplices) those transcripts into the instructions needed for making proteins.

Berkeley Lab Researchers Identify Structure of Key Control Element Behind Protein Misfolding That Can Lead to Diseas.

The gold standard for nanotechnology is nature’s own proteins. These biomolecular nanomachines – macromolecules forged from peptide chains of amino acids – are able to fold themselves into a dazzling multitude of shapes and forms that enable them to carry out an equally dazzling multitude of functions fundamental to life. As important as protein folding is to virtually all biological systems, the mechanisms behind this process have remained a mystery. The fog, however, is being lifted.

PHILADELPHIA — A protein's function depends on both the chains of molecules it is made of and the way those chains are folded. And while figuring out the former is relatively easy, the latter represents a huge challenge with serious implications because many diseases are the result of misfolded proteins. Now, a team of chemists at the University of Pennsylvania has devised a way to watch proteins fold in "real-time," which could lead to a better understanding of protein folding and misfolding in general.

Normally used to spot where people live, satellite images of nighttime lights can help keep tabs on the diseases festering among them, too, according to new research.

Princeton University-led researchers report in the journal Science Dec. 9 that nighttime-lights imagery presents a new tool for pinpointing disease hotspots in developing nations by revealing the population boom that typically coincides with seasonal epidemics. In urban areas with migratory populations, the images can indicate where people are clustering by capturing the expansion and increasing brightness of lighted areas. The researchers found the technique accurately indicates fluctuations in population density — and thus the risk of epidemic — that can elude current methods of monitoring outbreaks.

The human genome and the endowments of genes in other animals and plants are like a deck of poker cards containing a "wild card" that in a genetic sense introduces an element of variety and surprise that has a key role in life. That's what scientists are describing in a review of more than 100 studies on the topic that appears in ACS Chemical Biology.