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Friday, 07 August 2009 14:37 |
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Bob Weinberg is a Founding Member of the Whitehead Institute for Biomedical Research and Professor of Biology at the Massachusetts Institute of Technology. The Weinberg lab is known for its discoveries of the first human oncogene – the ras oncogene that causes normal cells to form tumors, and the isolation of the first known tumor suppressor gene - the Rb gene.
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Friday, 31 July 2009 15:26 |
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Jeffery Molkentin is Professor of Pediatrics at the Cincinnati Children's Hospital Medical Center. He received his B.S. in biology from Marquette University and his Ph.D. in physiology from the Medical College of Wisconsin, Milwaukee. He has received an American Heart Association Council on Basic Cardiovascular Sciences Research Prize and a Louis N. and Arnold M. Katz Young Investigator Award, and has been named a Pew Scholar.
The laboratory is interested in understanding the intracellular signaling pathways and transcriptional regulatory circuits that control mammalian cell growth and differentiation. In response to various growth factors or stress stimuli, discrete signal transduction pathways are activated at the cell membrane and within the cytoplasm that subsequently modify the activity of key transcription factors resulting in the reprogramming of gene expression. Important model systems for the investigation of growth and stress responses include cardiac myocytes, skeletal muscle myocytes, and T lymphocytes. |
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Friday, 24 July 2009 13:44 |
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David Goldstein is Professor of Molecular Genetics & Microbiology and Director of the IGSP's Center for Population Genomics & Pharmacogenetics. Dr. Goldstein received his PhD in Biological Sciences from Stanford University in 1994, and from 1999 to 2005 was Wolfson Professor of Genetics at University College London.
He is the author of over 70 scholarly publications in the areas of population and medical genetics. Goldstein's principal interests include human genetic diversity, the genetics of neurological disease, and pharmacogenetics. He is on the editorial boards of Current Biology, Annals of Human Genetics, Molecular Biology and Evolution, and Human Genomics. He is the recipient of one of the first seven nationally awarded Royal Society / Wolfson research merit awards in the UK for his work in human population genetics. |
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Tuesday, 30 June 2009 18:30 |
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The research in Dr. James Broach's laboratory at Department of Molecular Biology, Princeton University, is directed toward understanding cellular regulation at the molecular level, using the yeast Saccharomyces cerevisiae as a model system. Specifically, they are investigating (l) signal transduction regulating initiation of cell growth, and (2) the mechanism underlying the control of cell type in yeast. They approach these problems using a combination of yeast genetics, biochemical analysis, cell biology and genomic techniques.
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Friday, 29 May 2009 21:14 |
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Like a movie with multiple plots spiraling around an intriguing lead character, Harvard Medical School associate professor George Daley's scientific career centers on a major player in human biology—the cell that creates the entire array of blood cells.
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Tuesday, 05 May 2009 15:50 |
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Dr. Marvin Wicken lab's work at University of Wisconsin, Madison lies at the interface between developmental biology, molecular genetics and biochemistry. How are mRNAs controlled?
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Monday, 20 April 2009 21:37 |
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Carolyn Bertozzi, Professor of UC, Berkeley, is recognized as one of the leading scientists in chemcial biology. Bertozzi’s research interests lie at the intersection of chemistry and biology, with a particular focus on understanding the relationship of cell surface glycosylation to normal cell function, and to human disease.
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Wednesday, 08 April 2009 21:09 |
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Proteases play key roles in the regulation of normal and pathological processes ranging from cell division to invasion of a host cell by a pathogen. Dr. Matthew Bogyo’s laboratory, Stanford University, School of Medicine, is interested in developing and applying chemical tools to dissect the functional roles of proteases in a number of human health conditions.
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Friday, 27 March 2009 15:31 |
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William L. Jorgensen's lab is a pioneer computational chemistry research team by dedeveloping potential functions through fitting parameters to reproduce the thermodynamic properties of pure liquids, which is now widely used by other researchers. |
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Tuesday, 04 August 2009 04:36 |
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Bruce Spiegelman came to Harvard Medical School and the Dana-Farber Cancer Institute as an Assistant Professor, and was appointed Professor in 1991. Dr. Spiegelman received a B.S. with highest honors from the College of William and Mary, and a Ph.D. from Princeton University. His graduate work was immediately followed by postdoctoral research at the Massachusetts Institute of Technology. Dr. Spiegelman was elected to the National Academy of Science in 2002.
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Tuesday, 28 July 2009 07:33 |
The Seidman laboratory is the research base for a human molecular genetics program co-directed by Christine E. Seidman, MD and Jonathan G. Seidman, PhD. Located within the Departments of Genetics at Harvard Medical School and the Cardiovascular Division of Brigham and Womenís Hospital, the laboratory harnesses and integrates clinical medicine and molecular technologies to define disease-causing gene mutations and genetic variations that increase disease risk. |
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Tuesday, 21 July 2009 17:47 |
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Dr Xiaowei Zhuang is the professor of Chemistry and Chemistry Biology, in the Harvard Univerisy. The Zhuang research lab works on the forefront of single-molecule biology and bioimaging, developing and applying advanced optical imaging techniques to study the behavior of individual biological molecules and complexes in vitro and in live cells. Students in the Zhuang lab apply their diverse backgrounds in biology, chemistry, physics and engineering to develop new imaging methods and applying these methods to a variety of interesting biological systems. Their current research is focused on three major directions: (1) Developing super-resolution optical microscopy that allows cell and tissue imaging with nanoscopic scale resolution and applying this technology to cell biology and neurobiology, (2) investigating how biomolecules function, especially how proteins and nucleic acids interact, using single-molecule fluorescence imaging and spectroscopy; (3) developing live-cell imaging techniques for studying cellular dynamics, in particular virus-cell interactions.
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Wednesday, 10 June 2009 11:37 |
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Dr. Pellecchia’s research group at Burnham Institute for Medical Research focuses on the characterization of intermolecular interactions, on the determination of protein structures and on the development of small molecule inhibitors of protein targets involved in cell-signaling, virulence factors and host-pathogens interactions.
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Thursday, 14 May 2009 10:56 |
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Dr. Kenneth Kosik's research team at UC, Santa Barbara is interested in both the mechanisms of neuronal plasticity and its impairment in neurodegeneration. One facet of plasticity is the regulation of mRNA translocation and translation in dendrites. RNAs are not uniformly distributed in neurons, and a subset of mRNAs that extend into dendrites appear to position their translation products strategically to implement the morphological changes associated with activity-related changes in synapses.
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Monday, 27 April 2009 22:00 |
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Dr. M. G. Finn's group in The Scripps Research Institute engages in a wide variety of collaborative interactions within Scripps and with scientists around the world.
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Wednesday, 15 April 2009 20:37 |
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We may never know what primordial molecule gave birth to the very first organisms on Earth, yet accumulating evidence indicates that RNA is a strong contender—a single type of molecule that might have been the chief carrier of genetic information and the chief catalyst of replication. And this hypothesis—known by its shorthand name, "RNA World"—appears increasingly plausible because of the work of David Bartel, Professor of Biology at the Massachusetts Institute of Technology, Member of the Whitehead Institute, and Molecular Biologist at Massachusetts General Hospital, Boston.
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Friday, 03 April 2009 12:17 |
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 In recent years, due to contributions from numerous research groups, single-molecule experiments have changed the way many biological problems are addressed. Knowledge from these experiments continues to emerge. Dr. Xiaoliang Sunney Xie’s group, Department of Chemistry, Harvard, is one of the first to pioneer fluorescence studies of single molecules at room temperature in early 1990s and has since made important advances in single-molecule enzymology and protein conformational dynamics. Dr. Xie’s work has been credited not only for bringing about technological innovations, but also for generating new insights on important scientific issues. |
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Friday, 06 March 2009 11:32 |
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 | | "I think there are all kinds of applications [for the technique]," says Professor James Paulson, shown here with co-authors Ramya Chakravarthy (left) and Ying Zeng. "It will be up to the imagination of the community." | Glycoproteins are proteins bound to sugars that are ubiquitous in animal cells, but have proven especially challenging to study, limiting pharmaceutical applications and basic research. But a team of Scripps Research Institute scientists has now developed a technique that offers a 10-fold improvement in the critical process of labeling glycoproteins. This opens the possibility of new studies to identify cancer biomarkers that will allow early cancer diagnoses, among numerous applications. |
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